amx-2

Caenorhabditis elegans

Predicted to enable oxidoreductase activity. Predicted to be located in mitochondrial outer membrane. Expressed in several structures, including HSN; anus; pharyngeal muscle cell; rectal epithelium; and vulva. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Brunner Syndrome; alcohol use disorder; and panic disorder. Is an ortholog of human MAOA (monoamine oxidase A).

Hlb426

Mus musculus

PHENOTYPE: Mice with this mutation exhibit elevated systolic blood pressure (142 +/- 12mm Hg). [provided by MGI curators]

Maoa

Homo sapiens

This gene is one of two neighboring gene family members that encode mitochondrial enzymes which catalyze the oxidative deamination of amines, such as dopamine, norepinephrine, and serotonin. Mutation of this gene results in Brunner syndrome. This gene has also been associated with a variety of other psychiatric disorders, including antisocial behavior. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012]

Maoa

Rattus norvegicus

Enables heterocyclic compound binding activity and oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor. Involved in phenylethylamine metabolic process and serotonin metabolic process. Located in mitochondrial outer membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease; Brunner Syndrome; alcohol use disorder; autism spectrum disorder; and panic disorder. Orthologous to human MAOA (monoamine oxidase A); PARTICIPATES IN alkaptonuria pathway; citalopram pharmacodynamics pathway; citalopram pharmacokinetics pathway; INTERACTS WITH (+)-catechin; (5-hydroxyindol-3-yl)acetic acid; 17beta-estradiol.

YCF1

Saccharomyces cerevisiae

Vacuolar glutathione S-conjugate transporter; ABC-C transporter of the ATP-binding cassette family; required for vacuole fusion; forms stable complexes with vacuole fusion machinery; regulates Vam7p recruitment to vacuoles; role in detoxifying metals (Cd, Hg, As); transports GSSG that is not immediately reduced in cytosol to vacuole; transports unconjugated bilirubin, selenodigluthatione, oxidized glutathione; similar to human cystic fibrosis protein CFTR