rft-1

Caenorhabditis elegans

Enables riboflavin transmembrane transporter activity. Involved in embryo development. Predicted to be located in plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including Brown-Vialetto-Van Laere syndrome 1; Brown-Vialetto-Van Laere syndrome 2; and Fazio-Londe disease. Is an ortholog of human SLC52A2 (solute carrier family 52 member 2) and SLC52A3 (solute carrier family 52 member 3).

rft-2

Caenorhabditis elegans

Enables riboflavin transmembrane transporter activity. Involved in IRE1-mediated unfolded protein response. Predicted to be located in plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including Brown-Vialetto-Van Laere syndrome 1; Brown-Vialetto-Van Laere syndrome 2; and Fazio-Londe disease. Is an ortholog of human SLC52A1 (solute carrier family 52 member 1); SLC52A2 (solute carrier family 52 member 2); and SLC52A3 (solute carrier family 52 member 3).

chw-1

Caenorhabditis elegans

Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Involved in establishment or maintenance of cell polarity and vulval development. Predicted to be located in plasma membrane. Expressed in several structures, including P3.pa; P3.pp; P4.pa; P4.pp; and P8.pa. Is an ortholog of human RHOU (ras homolog family member U).

nlp-26

Caenorhabditis elegans

Predicted to be involved in neuropeptide signaling pathway. Expressed in several structures, including P2.p; P3.pa; P3.pp; P4.pa; and P4.pp.

brwd

Mus musculus

PHENOTYPE: Mutant mice have a brown coat color. [provided by MGI curators]

Bola3

Mus musculus

PHENOTYPE: Mice in which the gene is deleted in fat tissue, show impaired glucose tolerance, impaired norepinephrine-induced brown adipose tissue thermogenesis, increased weight gain at thermoneutral temperature and decreased brown adipose tissue glucose uptake [provided by MGI curators]

let-765

Caenorhabditis elegans

Predicted to enable chromatin DNA binding activity and histone binding activity. Involved in several processes, including nematode male tail tip morphogenesis; positive regulation of Ras protein signal transduction; and vulval cell fate specification. Located in nucleus. Expressed in several structures, including P3.pa; P3.pp; P4.pa; P5.ppp; and P7.paa. Is an ortholog of human SBNO1 (strawberry notch homolog 1).

Prr30

Homo sapiens

ASSOCIATED WITH Tatton-Brown-Rahman syndrome; INTERACTS WITH aflatoxin B1; benzo[a]pyrene; valproic acid

D1081.19

Caenorhabditis elegans

Is affected by several genes including nuo-6; ash-2; and isp-1 based on RNA-seq and microarray studies. Is affected by six chemicals including Atrazine; cadmium; and fluoranthene based on microarray studies. Is predicted to encode a protein with the following domains: Peptidase S1, PA clan, chymotrypsin-like fold; Peptidase S1, PA clan; Nematode trypsin-6-like family; and Chymotrypsin family Peptidase-S1.

Rgsc798

Mus musculus

PHENOTYPE: Mice with a mutation of this gene have brown fur. [provided by MGI curators]