larp-5

Caenorhabditis elegans

Predicted to enable mRNA 3'-UTR binding activity. Predicted to be involved in positive regulation of translation. Predicted to be located in cytoplasmic stress granule and cytosol. Expressed in PVDL; PVDR; and neurons. Is an ortholog of human LARP4 (La ribonucleoprotein 4) and LARP4B (La ribonucleoprotein 4B).

rft-1

Caenorhabditis elegans

Enables riboflavin transmembrane transporter activity. Involved in embryo development. Predicted to be located in plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including Brown-Vialetto-Van Laere syndrome 1; Brown-Vialetto-Van Laere syndrome 2; and Fazio-Londe disease. Is an ortholog of human SLC52A2 (solute carrier family 52 member 2) and SLC52A3 (solute carrier family 52 member 3).

rft-2

Caenorhabditis elegans

Enables riboflavin transmembrane transporter activity. Involved in IRE1-mediated unfolded protein response. Predicted to be located in plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including Brown-Vialetto-Van Laere syndrome 1; Brown-Vialetto-Van Laere syndrome 2; and Fazio-Londe disease. Is an ortholog of human SLC52A1 (solute carrier family 52 member 1); SLC52A2 (solute carrier family 52 member 2); and SLC52A3 (solute carrier family 52 member 3).

larp-1

Caenorhabditis elegans

Enables poly(G) binding activity and poly(U) RNA binding activity. Predicted to be involved in positive regulation of translation. Located in P-body. Expressed in germ line; head; and tail. Is an ortholog of human LARP1 (La ribonucleoprotein 1, translational regulator) and LARP1B (La ribonucleoprotein 1B).

PGRP-LA

Drosophila melanogaster

Peptidoglycan recognition protein LA (PGRP-LA) encodes a protein implicated in the regulation of the immune deficiency pathway in some epithelia.

tdo-2

Caenorhabditis elegans

Predicted to enable heme binding activity and tryptophan 2,3-dioxygenase activity. Predicted to be involved in tryptophan catabolic process to acetyl-CoA. Human ortholog(s) of this gene implicated in Gilles de la Tourette syndrome and familial hypertryptophanemia. Is an ortholog of human TDO2 (tryptophan 2,3-dioxygenase).

ssb-1

Caenorhabditis elegans

Predicted to enable mRNA binding activity. Predicted to be involved in positive regulation of translation and tRNA processing. Predicted to be located in cytoplasmic stress granule; cytosol; and nucleus. Predicted to be part of ribonucleoprotein complex. Expressed in head and tail. Is an ortholog of human SSB (small RNA binding exonuclease protection factor La).

brwd

Mus musculus

PHENOTYPE: Mutant mice have a brown coat color. [provided by MGI curators]

Larp1b

Homo sapiens

This gene encodes a protein containing domains found in the La related protein of Drosophila melanogaster. La motif-containing proteins are thought to be RNA-binding proteins, where the La motif and adjacent amino acids fold into an RNA recognition motif. The La motif is also found in proteins unrelated to the La protein. Alternative splicing has been observed at this locus and multiple variants, encoding distinct isoforms, are described. Additional splice variation has been identified but the full-length nature of these transcripts has not been determined. [provided by RefSeq, Jun 2013]

SRAE_X000075200

Strongyloides ratti

Is predicted to encode a protein with the following domains: La domain; Winged helix DNA-binding domain superfamily; La-type HTH domain; and Winged helix-like DNA-binding domain superfamily.