rft-1

Caenorhabditis elegans

Enables riboflavin transmembrane transporter activity. Involved in embryo development. Predicted to be located in plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including Brown-Vialetto-Van Laere syndrome 1; Brown-Vialetto-Van Laere syndrome 2; and Fazio-Londe disease. Is an ortholog of human SLC52A2 (solute carrier family 52 member 2) and SLC52A3 (solute carrier family 52 member 3).

rft-2

Caenorhabditis elegans

Enables riboflavin transmembrane transporter activity. Involved in IRE1-mediated unfolded protein response. Predicted to be located in plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including Brown-Vialetto-Van Laere syndrome 1; Brown-Vialetto-Van Laere syndrome 2; and Fazio-Londe disease. Is an ortholog of human SLC52A1 (solute carrier family 52 member 1); SLC52A2 (solute carrier family 52 member 2); and SLC52A3 (solute carrier family 52 member 3).

wht-6

Caenorhabditis elegans

Predicted to enable ATPase-coupled transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in plasma membrane. Expressed in intestine. Human ortholog(s) of this gene implicated in several diseases, including gout; hematologic cancer (multiple); and toxic encephalopathy. Is an ortholog of human ABCG2 (ATP binding cassette subfamily G member 2 (JR blood group)).

wht-5

Caenorhabditis elegans

Predicted to enable ATPase-coupled transmembrane transporter activity. Involved in positive regulation of nematode male tail tip morphogenesis. Predicted to be located in plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including gout; hematologic cancer (multiple); and toxic encephalopathy. Is an ortholog of human ABCG2 (ATP binding cassette subfamily G member 2 (JR blood group)).

wht-8

Caenorhabditis elegans

Predicted to enable ATPase-coupled transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including gout; hematologic cancer (multiple); and toxic encephalopathy. Is an ortholog of human ABCG2 (ATP binding cassette subfamily G member 2 (JR blood group)).

wht-4

Caenorhabditis elegans

Predicted to enable ATPase-coupled transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including gout; hematologic cancer (multiple); and toxic encephalopathy. Is an ortholog of human ABCG1 (ATP binding cassette subfamily G member 1); ABCG2 (ATP binding cassette subfamily G member 2 (JR blood group)); and ABCG4 (ATP binding cassette subfamily G member 4).

brwd

Mus musculus

PHENOTYPE: Mutant mice have a brown coat color. [provided by MGI curators]

wht-1

Caenorhabditis elegans

Predicted to enable ATPase-coupled transmembrane transporter activity. Involved in regulatory ncRNA-mediated post-transcriptional gene silencing. Predicted to be located in plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including gout; hematologic cancer (multiple); and toxic encephalopathy. Is an ortholog of human ABCG2 (ATP binding cassette subfamily G member 2 (JR blood group)).

Bola3

Mus musculus

PHENOTYPE: Mice in which the gene is deleted in fat tissue, show impaired glucose tolerance, impaired norepinephrine-induced brown adipose tissue thermogenesis, increased weight gain at thermoneutral temperature and decreased brown adipose tissue glucose uptake [provided by MGI curators]

Prr30

Homo sapiens

ASSOCIATED WITH Tatton-Brown-Rahman syndrome; INTERACTS WITH aflatoxin B1; benzo[a]pyrene; valproic acid