- bowl [Search on AGR]
Drosophila melanogaster brother of odd with entrails limited (bowl) encodes a member of the Odd-skipped (Odd) family of zinc finger proteins involved in developmental patterning and cell fate specification. Its localization in the nucleus is regulated by the nuclear protein encoded by lin and the the product of drm with opposing roles.
- lin [Search on AGR]
Drosophila melanogaster lines (lin) encodes a nuclear protein involved in developmental patterning and cell fate specification. The Odd-skipped family protein encoded by bowl binds to and destabilizes the product of lin in the nucleus. Converserly the Odd family protein encoded by drm stabilizes the product of bowl in the nucleus by outcompeting the binding of the product of lin to the product of bowl and localizing the product of lin to the cytoplasm.
- drm [Search on AGR]
Drosophila melanogaster drumstick (drm) encodes a member of the Odd-skipped (Odd) family of zinc finger proteins involved in developmental patterning and cell fate specification. It stabilizes the related Odd family protein encoded by bowl in the nucleus by outcompeting the binding of the nuclear protein encoded by lin to the product of bowl and localizing the product of lin to the cytoplasm.
- Il2 [Search on AGR]
Mus musculus PHENOTYPE: Homozygous null mutants develop adult onset autoimmune disease, with 50% mortality by 9 weeks due to hemolytic anemia. Survivors develop inflammatory bowl disease/colitis. Immune system dysregulation and CD4+ T-cell overproduction may be responsible. [provided by MGI curators]