- emg-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable rRNA (pseudouridine) methyltransferase activity and rRNA binding activity. Predicted to be involved in rRNA base methylation. Predicted to be located in nucleolus. Predicted to be part of small-subunit processome. Human ortholog(s) of this gene implicated in Bowen-Conradi syndrome. Is an ortholog of human EMG1 (EMG1 N1-specific pseudouridine methyltransferase).
- Rep2 [Search on AGR]
Mus musculus PHENOTYPE: Analysis of congenic strains located genes Rep1 and Rep2 controlling chromatin damage repair efficiency. NZB/NJ and BALB/cAn show inefficient repair with >100 breaks per 100 metaphase cells 2 hrs after X-irradiation of skin fibroblasts. Most strains havean efficient repair phenotype. [provided by MGI curators]
- Emg1 [Search on AGR]
Saccharomyces cerevisiae Methyltransferase for rRNA; methylates pseudouridine 18S rRNA residue 1191; member of the SPOUT methyltransferase family; required for maturation of 18S rRNA and for 40S ribosomal subunit production independent of methyltransferase activity; forms homodimers; human ortholog is mutated in Bowen-Conradi syndrome, and equivalent yeast mutation affects Emg1p dimerization and localization but not methyltransferase activity; human EMG1 complements lethality of null and ts mutant
- Rep1 [Search on AGR]
Mus musculus PHENOTYPE: Analysis of congenic strains located genes Rep1 and Rep2 controlling chromatin damage repair efficiency. NZB/NJ and BALB/cAn show inefficient repair with >100 breaks per 100 metaphase cells 2 hrs after X-irradiation of skin fibroblasts. Most strains havean efficient repair phenotype. [provided by MGI curators]
- Emg1 [Search on AGR]
Homo sapiens This gene encodes an essential, conserved eukaryotic protein that methylates pseudouridine in 18S rRNA. The related protein in yeast is a component of the small subunit processome and is essential for biogenesis of the ribosomal 40S subunit. A mutation in this gene has been associated with Bowen-Conradi syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
- Emg1 [Search on AGR]
Rattus norvegicus Predicted to enable identical protein binding activity; rRNA (pseudouridine) methyltransferase activity; and rRNA binding activity. Predicted to be involved in rRNA base methylation and ribosomal small subunit biogenesis. Predicted to act upstream of or within blastocyst development and nucleologenesis. Predicted to be located in chromosome and nucleoplasm. Predicted to be part of small-subunit processome. Predicted to be active in nucleolus. Human ortholog(s) of this gene implicated in Bowen-Conradi syndrome. Orthologous to human EMG1 (EMG1 N1-specific pseudouridine methyltransferase); PARTICIPATES IN ribosome biogenesis pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 3-chloropropane-1,2-diol.