Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including cell fate commitment; embryonic pattern specification; and positive regulation of DNA-templated transcription. Located in condensed nuclear chromosome. Expressed in several structures, including ABprpppppaa; Caaaaa; enteric muscle; epithelial cell; and tail spike. Human ortholog(s) of this gene implicated in Barrett's esophagus. Is an ortholog of human CDX1 (caudal type homeobox 1) and CDX2 (caudal type homeobox 2).
Enables calcium ion binding activity. Located in basement membrane and extracellular space. Expressed in body wall musculature; gonad; head; pharynx; and vulval muscle. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); osteogenesis imperfecta type 17; and progressive osseous heteroplasia. Is an ortholog of human SPARC (secreted protein acidic and cysteine rich).
Enables receptor tyrosine kinase binding activity. Involved in several processes, including neuroblast migration; neuron migration; and positive regulation of axon guidance. Predicted to be located in extracellular space. Expressed in several structures, including CAN; hypodermal cell; intestine; muscle cell; and somatic nervous system. Human ortholog(s) of this gene implicated in Mullerian aplasia and hyperandrogenism and endometrial carcinoma. Is an ortholog of human WNT4 (Wnt family member 4).
Predicted to enable metal ion binding activity and serine-type endopeptidase inhibitor activity. Involved in axon development; cell adhesion mediated by integrin; and muscle attachment. Located in M band; basement membrane; and striated muscle dense body. Expressed in basal lamina; coelomocyte; excretory canal; and pharynx. Is an ortholog of human SPON1 (spondin 1).
Predicted to enable mRNA binding activity. Predicted to be involved in nervous system development and regulation of alternative mRNA splicing, via spliceosome. Located in P granule. Expressed in several structures, including D; Psub4; Z2; Z3; and germ line.
Involved in several processes, including body morphogenesis; inductive cell migration; and system development. Located in nucleus and plasma membrane. Expressed in several structures, including body muscle cell; gonad; hypodermis; interfacial epithelial cell; and neurons. Human ortholog(s) of this gene implicated in cocaine dependence and essential tremor 5. Is an ortholog of human TENM2 (teneurin transmembrane protein 2) and TENM3 (teneurin transmembrane protein 3).
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including dauer exit; determination of adult lifespan; and negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed in several structures, including MSpa; anal depressor muscle; body wall musculature; intestinal cell; and neurons.
Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and protein homodimerization activity. Involved in positive regulation of mesodermal cell fate specification; positive regulation of transcription by RNA polymerase II; and striated muscle cell differentiation. Acts upstream of or within positive regulation of muscle cell differentiation. Located in nucleus. Expressed in several structures, including C lineage cell; D lineage cell; I4 neuron; MSaaaapa; and body wall muscle cell. Used to study Duchenne muscular dystrophy. Human ortholog(s) of this gene implicated in congenital myopathy 17 and congenital structural myopathy. Is an ortholog of several human genes including MYF5 (myogenic factor 5); MYF6 (myogenic factor 6); and MYOD1 (myogenic differentiation 1).