ceh-48

Caenorhabditis elegans

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed in head; neurons; spermathecal-uterine junction; ventral nerve cord; and vulva. Is an ortholog of human ONECUT1 (one cut homeobox 1); ONECUT2 (one cut homeobox 2); and ONECUT3 (one cut homeobox 3).

cut-2

Caenorhabditis elegans

Predicted to be a structural constituent of cuticle. Predicted to be located in extracellular region.

ceh-44

Caenorhabditis elegans

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed in head muscle; neurons; and somatic nervous system. Human ortholog(s) of this gene implicated in several diseases, including developmental and epileptic encephalopathy 67; gastrointestinal system cancer (multiple); and insulinoma. Is an ortholog of human CUX2 (cut like homeobox 2).

ceh-39

Caenorhabditis elegans

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II and primary sex determination. Located in condensed nuclear chromosome and germ cell nucleus. Expressed in body wall musculature; germ line; gonad; neurons; and ventral nerve cord.

ceh-49

Caenorhabditis elegans

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed in coelomocyte; head muscle; head neurons; intestine; and somatic nervous system.

R05D3.12

Caenorhabditis elegans

Predicted to enable DNA binding activity; DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity; and small molecule binding activity. Predicted to be involved in resolution of meiotic recombination intermediates and sister chromatid segregation. Predicted to be located in nucleus.

cut-1

Caenorhabditis elegans

Predicted to be a structural constituent of cuticle. Located in collagen and cuticulin-based cuticle extracellular matrix. Expressed in cuticle and seam cell.

ceh-21

Caenorhabditis elegans

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed widely.

top-3B

Caenorhabditis elegans

Predicted to enable DNA topoisomerase type I (single strand cut, ATP-independent) activity. Predicted to be involved in DNA recombination; DNA repair; and DNA topological change. Predicted to be located in nucleus. Expressed in head. Is an ortholog of human TOP3B (DNA topoisomerase III beta).

cin-4

Caenorhabditis elegans

Predicted to enable ATP binding activity; DNA binding activity; and DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity. Predicted to be involved in resolution of meiotic recombination intermediates and sister chromatid segregation. Predicted to be located in nucleus. Is an ortholog of human TOP2B (DNA topoisomerase II beta).