- morc-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables topological DNA co-entrapment activity. Involved in DNA topological change. Located in nuclear body. Expressed in somatic cell. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2Z. Is an ortholog of human MORC1 (MORC family CW-type zinc finger 1).
- Zcwpw1l1 [Search on AGR]
Rattus norvegicus Predicted to enable methylated histone binding activity. Predicted to be active in nucleus. Orthologous to human ZCWPW1 (zinc finger CW-type and PWWP domain containing 1); INTERACTS WITH dioxygen.
- Zcwpw2 [Search on AGR]
Rattus norvegicus Predicted to enable methylated histone binding activity. Orthologous to human ZCWPW2 (zinc finger CW-type and PWWP domain containing 2); INTERACTS WITH bisphenol A; Tesaglitazar; (+)-catechin (ortholog).
- Morc4 [Search on AGR]
Rattus norvegicus Predicted to enable methylated histone binding activity. Predicted to be active in nucleoplasm. Orthologous to human MORC4 (MORC family CW-type zinc finger 4); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; atrazine; bisphenol A.
- Morc2b [Search on AGR]
Rattus norvegicus Predicted to enable zinc ion binding activity. Predicted to be involved in double-strand break repair involved in meiotic recombination; gamete generation; and homologous chromosome pairing at meiosis. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2Z. Orthologous to human MORC2 (MORC family CW-type zinc finger 2).
- Morc1 [Search on AGR]
Rattus norvegicus Predicted to enable zinc ion binding activity. Predicted to be involved in negative regulation of gene expression. Predicted to act upstream of or within several processes, including behavioral fear response; regulation of gene expression; and retrotransposon silencing by heterochromatin formation. Predicted to be active in male germ cell nucleus. Orthologous to human MORC1 (MORC family CW-type zinc finger 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; atrazine.
- Zcwpw1 [Search on AGR]
Rattus norvegicus Predicted to enable histone reader activity; methyl-CpG binding activity; and methylated histone binding activity. Predicted to be involved in meiosis I; positive regulation of DNA metabolic process; and spermatogenesis. Predicted to act upstream of or within homologous chromosome pairing at meiosis. Predicted to be located in XY body and nucleus. Orthologous to human ZCWPW1 (zinc finger CW-type and PWWP domain containing 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-amino-4,6-dinitrotoluene; 6-propyl-2-thiouracil.
- Morc2 [Search on AGR]
Rattus norvegicus Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and metal ion binding activity. Predicted to be involved in DNA damage response and regulation of macromolecule biosynthetic process. Predicted to be located in cytosol; nuclear matrix; and nucleoplasm. Predicted to be part of heterochromatin. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2Z. Orthologous to human MORC2 (MORC family CW-type zinc finger 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acrylamide; all-trans-retinoic acid.
- Morc4 [Search on AGR]
Homo sapiens In human, the four current members of the microrchidia (morc) gene family share an N-terminal ATPase-like ATP-binding region and a CW four-cysteine zinc-finger motif. The protein encoded by this gene also has a nuclear matrix binding domain and a two-stranded coiled-coil motif near its C-terminus. This gene is widely expressed at low levels in normal tissues and has elevated expression in placenta and testis. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jan 2010]
- Morc3 [Search on AGR]
Rattus norvegicus Predicted to enable DNA binding activity; methylated histone binding activity; and protein-macromolecule adaptor activity. Predicted to be involved in antiviral innate immune response; negative regulation of interferon-beta production; and negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including maintenance of protein location in nucleus; positive regulation of cellular senescence; and protein stabilization. Predicted to be located in nucleoplasm. Predicted to be part of chromatin. Predicted to be active in PML body. Orthologous to human MORC3 (MORC family CW-type zinc finger 3); INTERACTS WITH 2,4-dinitrotoluene; azoxystrobin; bisphenol A.