T13G4.4

Caenorhabditis elegans

Predicted to enable S-adenosylmethionine-homocysteine S-methyltransferase activity. Predicted to be involved in S-methylmethionine cycle and methionine biosynthetic process.

Y47C4A.1

Caenorhabditis elegans

Predicted to enable metalloendopeptidase activity. Predicted to be involved in mitochondrial protein processing. Predicted to be part of m-AAA complex. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 7. Is an ortholog of human SPG7 (SPG7 matrix AAA peptidase subunit, paraplegin).

gst-34

Caenorhabditis elegans

Predicted to enable glutathione transferase activity. Human ortholog(s) of this gene implicated in asthma and ovarian cancer. Is an ortholog of several human genes including GSTA1 (glutathione S-transferase alpha 1); GSTA2 (glutathione S-transferase alpha 2); and GSTA3 (glutathione S-transferase alpha 3).

W10C8.4

Caenorhabditis elegans

Predicted to enable glutathione transferase activity. Human ortholog(s) of this gene implicated in asthma and ovarian cancer. Is an ortholog of several human genes including GSTA1 (glutathione S-transferase alpha 1); GSTA2 (glutathione S-transferase alpha 2); and GSTA3 (glutathione S-transferase alpha 3).

gst-35

Caenorhabditis elegans

Predicted to enable glutathione transferase activity. Human ortholog(s) of this gene implicated in asthma and ovarian cancer. Is an ortholog of several human genes including GSTA1 (glutathione S-transferase alpha 1); GSTA2 (glutathione S-transferase alpha 2); and GSTA3 (glutathione S-transferase alpha 3).

ppgn-1

Caenorhabditis elegans

Predicted to enable metalloendopeptidase activity. Predicted to be involved in mitochondrial protein processing. Predicted to be located in membrane. Predicted to be part of m-AAA complex. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 7. Is an ortholog of human SPG7 (SPG7 matrix AAA peptidase subunit, paraplegin).

msra-1

Caenorhabditis elegans

Enables L-methionine:thioredoxin-disulfide S-oxidoreductase activity and peptide-methionine (S)-S-oxide reductase activity. Predicted to be involved in cellular response to oxidative stress. Predicted to be located in cytoplasm. Expressed in hypodermis and neurons. Is an ortholog of human MSRA (methionine sulfoxide reductase A).

nekl-4

Caenorhabditis elegans

Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in regulation of cell cycle G2/M phase transition. Expressed in PQR; amphid neurons; ciliated neurons; and phasmid neurons. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 44. Is an ortholog of human NEK10 (NIMA related kinase 10).

gtl-1

Caenorhabditis elegans

Predicted to enable monoatomic cation channel activity. Involved in defecation. Predicted to be located in plasma membrane. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis-parkinsonism/dementia complex 1; cataract; and congenital stationary night blindness 1C. Is an ortholog of human TRPM1 (transient receptor potential cation channel subfamily M member 1); TRPM3 (transient receptor potential cation channel subfamily M member 3); and TRPM7 (transient receptor potential cation channel subfamily M member 7).

slc-25A26

Caenorhabditis elegans

Enables S-adenosyl-L-methionine transmembrane transporter activity. Involved in mitochondrial S-adenosyl-L-methionine transmembrane transport. Located in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 28. Is an ortholog of human SLC25A26 (solute carrier family 25 member 26).