ser-4

Caenorhabditis elegans

Enables G protein-coupled serotonin receptor activity. Involved in regulation of locomotion and serotonin receptor signaling pathway. Predicted to be located in dendrite and plasma membrane. Expressed in neurons; vm2; and vulval cell. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; alcohol dependence; attention deficit hyperactivity disorder; and conduct disorder. Is an ortholog of human HTR1A (5-hydroxytryptamine receptor 1A).

dop-5

Caenorhabditis elegans

Predicted to enable G protein-coupled serotonin receptor activity and neurotransmitter receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger and chemical synaptic transmission. Predicted to be located in dendrite and plasma membrane. Expressed in neurons.

ser-7

Caenorhabditis elegans

Predicted to enable G protein-coupled serotonin receptor activity and neurotransmitter receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger and chemical synaptic transmission. Located in membrane. Expressed in egg-laying apparatus and pharyngeal neurons. Human ortholog(s) of this gene implicated in alcohol use disorder. Is an ortholog of human HTR7 (5-hydroxytryptamine receptor 7).

ser-3

Caenorhabditis elegans

Enables octopamine receptor activity. Involved in octopamine or tyramine signaling pathway. Predicted to be located in dendrite and plasma membrane. Expressed in several structures, including ASH; SIA; head muscle; hermaphrodite gonad; and lumbar ganglion.

Nmb

Mus musculus

PHENOTYPE: Mice homozygous for a knockout allele exhibit attenuated scratching in response to histamine, compound 48/80 and 5-HT. [provided by MGI curators]

mpz-1

Caenorhabditis elegans

Enables GTPase activating protein binding activity. Located in axon. Expressed in body wall musculature; nerve ring; neurons; and vulval muscle. Human ortholog(s) of this gene implicated in hydrocephalus. Is an ortholog of human MPDZ (multiple PDZ domain crumbs cell polarity complex component) and PATJ (PATJ crumbs cell polarity complex component).

ser-1

Caenorhabditis elegans

Enables G protein-coupled serotonin receptor activity and serotonin binding activity. Involved in several processes, including reproductive behavior; response to heat; and signal transduction. Located in plasma membrane. Expressed in several structures, including egg-laying apparatus; intestine; neurons; pharyngeal muscle cell; and somatic nervous system. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; alcoholic psychosis; and metabolic dysfunction-associated steatotic liver disease (multiple). Is an ortholog of human HTR2A (5-hydroxytryptamine receptor 2A) and HTR2B (5-hydroxytryptamine receptor 2B).

tyra-3

Caenorhabditis elegans

Predicted to enable G protein-coupled serotonin receptor activity; neurotransmitter receptor activity; and octopamine receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger and chemical synaptic transmission. Predicted to be located in dendrite and plasma membrane. Expressed in SDQ; gonad; head neurons; and vulva. Used to study Parkinson's disease.

Lpar1

Mus musculus

PHENOTYPE: Nullizygous mutations cause partial peri- and postnatal lethality, growth defects, craniofacial anomalies, and wide set eyes. Additional phenotypes include altered brain 5-HT and amino acids, reduced prepulse inhibition, impaired suckling, and increased apoptosis in sciatic nerve Schwann cells. [provided by MGI curators]

ser-5

Caenorhabditis elegans

Predicted to enable alpha1-adrenergic receptor activity. Involved in several processes, including nematode pharyngeal pumping; positive regulation of egg-laying behavior; and serotonin receptor signaling pathway. Predicted to be located in plasma membrane. Expressed in body wall musculature; egg-laying apparatus; and lateral ganglion. Human ortholog(s) of this gene implicated in Alzheimer's disease; heroin dependence; and hypertension. Is an ortholog of human ADRA1A (adrenoceptor alpha 1A) and ADRA1B (adrenoceptor alpha 1B).