Cd207

Mus musculus

PHENOTYPE: Nullizygous mice lack Birbeck granules with no marked loss of Langerhans cell (LC) function. Knock-in mice expressing diphtheria toxin (DT) receptors show LC depletion. Heterozygotes for a knock-in allele show DT-induced LC ablation, altered contact hypersensitivity and susceptibility to infection. [provided by MGI curators]

PGRP-LC

Drosophila melanogaster

Peptidoglycan recognition protein LC (PGRP-LC) encodes a transmembrane receptor involved in the recognition of DAP-type peptidoglycan, a cell wall component found on Gram-negative bacteria and certain Gram positive bacteria. It functions upstream of the immune deficiency pathway.

PGRP-LF

Drosophila melanogaster

Peptidoglycan recognition protein LF (PGRP-LF) encodes a transmembrane receptor that prevents the spontaneous activation of the immune deficiency pathway receptor encoded by PGRP-LC.

pirk

Drosophila melanogaster

poor Imd response upon knock-in (pirk) encodes a negative regulator of the immune deficiency (Imd) pathway, acting at the level of the product of PGRP-LC. Being regulated by the Imd pathway itself, it establishes a negative feedback loop adjusting Imd pathway activity to the severity of infection.