Klf9

Homo sapiens

The protein encoded by this gene is a transcription factor that binds to GC box elements located in the promoter. Binding of the encoded protein to a single GC box inhibits mRNA expression while binding to tandemly repeated GC box elements activates transcription. [provided by RefSeq, Jul 2008]

GC

Drosophila melanogaster

gamma-glutamyl carboxylase (GC) encodes an enzyme involved in peptidyl-glutamic acid carboxylation.

mog-7

Caenorhabditis elegans

Predicted to enable DNA binding activity. Predicted to be involved in spliceosomal complex disassembly. Predicted to be located in nucleus. Predicted to be part of U2-type post-mRNA release spliceosomal complex. Expressed in germ cell; oocyte; somatic cell; and sperm. Is an ortholog of human GCFC2 (GC-rich sequence DNA-binding factor 2) and PAXBP1 (PAX3 and PAX7 binding protein 1).

OVOC4924

Onchocerca volvulus

Is predicted to encode a protein with the following domains: GC-rich sequence DNA-binding factor-like protein and GCF, C-terminal.

GC

Rattus norvegicus

Enables vitamin D binding activity. Involved in several processes, including female pregnancy; lactation; and response to estradiol. Located in axon; extracellular space; and perinuclear region of cytoplasm. Biomarker of brain ischemia and hepatocellular carcinoma. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); chronic obstructive pulmonary disease; hepatocellular carcinoma; human immunodeficiency virus infectious disease; and rheumatic fever. Orthologous to human GC (GC vitamin D binding protein); INTERACTS WITH 1-naphthyl isothiocyanate; 2,6-dinitrotoluene; 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile.

Slc10a3

Homo sapiens

This gene maps to a GC-rich region of the X chromosome and was identified by its proximity to a CpG island. It is thought to be a housekeeping gene. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2008]

Gpbp1l1

Rattus norvegicus

Predicted to enable DNA binding activity and RNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be active in nucleus. Orthologous to human GPBP1L1 (GC-rich promoter binding protein 1 like 1); INTERACTS WITH 17beta-estradiol; 6-propyl-2-thiouracil; amitrole.

EndoG

Homo sapiens

The protein encoded by this gene is a nuclear encoded endonuclease that is localized in the mitochondrion. The encoded protein is widely distributed among animals and cleaves DNA at GC tracts. This protein is capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA. [provided by RefSeq, Jul 2008]

Klf13

Homo sapiens

KLF13 belongs to a family of transcription factors that contain 3 classical zinc finger DNA-binding domains consisting of a zinc atom tetrahedrally coordinated by 2 cysteines and 2 histidines (C2H2 motif). These transcription factors bind to GC-rich sequences and related GT and CACCC boxes (Scohy et al., 2000 [PubMed 11087666]).[supplied by OMIM, Mar 2008]

Sp6

Homo sapiens

SP6 belongs to a family of transcription factors that contain 3 classical zinc finger DNA-binding domains consisting of a zinc atom tetrahedrally coordinated by 2 cysteines and 2 histidines (C2H2 motif). These transcription factors bind to GC-rich sequences and related GT and CACCC boxes (Scohy et al., 2000 [PubMed 11087666]).[supplied by OMIM, Mar 2008]