- dkf-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables protein serine/threonine kinase activity. Involved in several processes, including defense response to Gram-positive bacterium; determination of adult lifespan; and positive regulation of protein import into nucleus. Acts upstream of or within with a positive effect on neuromuscular synaptic transmission. Located in several cellular components, including axon; cell cortex; and somatodendritic compartment. Expressed in neurons.
- Cfap410 [Search on AGR]
Homo sapiens Four alternatively spliced transcript variants encoding four different isoforms have been found for this nuclear gene. All isoforms contain leucine-rich repeats. Three of these isoforms are mitochondrial proteins and one of them lacks the target peptide, so is not located in mitochondrion. This gene is down-regulated in Down syndrome (DS) brain, which may represent mitochondrial dysfunction in DS patients. [provided by RefSeq, Sep 2012]
- wap [Search on AGR]
Drosophila melanogaster wings apart (wap) encodes a protein required for growth, viability, muscle development, and proper wing venation. It physically interacts with the product of ds, and functions in the Hippo pathway to regulate growth.
- lft [Search on AGR]
Drosophila melanogaster lowfat (lft) encodes a protein that influences Dachsous-Fat signaling by elevating levels of the products of ds and ft at apical membranes. Mutation of lft causes mild planar cell polarity and growth phenotypes.
- Dlish [Search on AGR]
Drosophila melanogaster Dachs ligand with SH3s (Dlish) encodes an adapter protein that can bind to the products of dachs, ds, and ft. It is required for the normal growth of wings and legs via Dachsous-Fat signaling.
- fj [Search on AGR]
Drosophila melanogaster four-jointed (fj) encodes a type II transmembrane kinase. Through phosphorylation of the atypical cadherins encoded by ft and ds, it regulates control of planar polarity in epithelia and also growth via the Hippo/Warts pathway.
- REC107 [Search on AGR]
Saccharomyces cerevisiae Protein involved in early stages of meiotic recombination; involved in coordination between the initiation of recombination and the first division of meiosis; part of a complex (Rec107p-Mei4p-Rec114p) required for ds break formation
- Ho [Search on AGR]
Saccharomyces cerevisiae Site-specific endonuclease; required for gene conversion at the MAT locus (homothallic switching) through the generation of a ds DNA break; expression restricted to mother cells in late G1 as controlled by Swi4p-Swi6p, Swi5p, and Ash1p
- cdh-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable calcium ion binding activity. Predicted to be involved in cell-cell adhesion. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in Van Maldergem syndrome 1 and mitral valve prolapse. Is an ortholog of human DCHS1 (dachsous cadherin-related 1) and DCHS2 (dachsous cadherin-related 2).
- Tlr3 [Search on AGR]
Mus musculus PHENOTYPE: Homozygotes for a null allele show alterations in innate immunity against different viruses, viral pathogenesis, anxiety, hippocampal synaptic plasticity, memory retention and neurogenesis. Homozygotes for another null allele show altered ds-RNA responses in dendritic and aorta smooth muscle cells. [provided by MGI curators]