Oscar

Rattus norvegicus

Predicted to enable collagen receptor activity. Predicted to be involved in immune response-regulating signaling pathway. Predicted to act upstream of or within Fc-gamma receptor signaling pathway; multinuclear osteoclast differentiation; and positive regulation of bone resorption. Predicted to be located in cell surface. Predicted to be active in plasma membrane. Orthologous to human OSCAR (osteoclast associated Ig-like receptor); INTERACTS WITH 3,4-methylenedioxymethamphetamine; amphetamine; bisphenol A.

Oscar

Homo sapiens

Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. This gene encodes an osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex protein family that plays critical roles in the regulation of both innate and adaptive immune responses. The encoded protein may play a role in oxidative stress-mediated atherogenesis as well as monocyte adhesion. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2013]