Akp3 [Search on AGR]
Rattus norvegicus Enables alkaline phosphatase activity; magnesium ion binding activity; and zinc ion binding activity. Involved in response to nutrient levels. Located in external side of plasma membrane. Human ortholog(s) of this gene implicated in inflammatory bowel disease. Orthologous to human ALPG (alkaline phosphatase, germ cell); ALPI (alkaline phosphatase, intestinal); and ALPP (alkaline phosphatase, placental); PARTICIPATES IN folate metabolic pathway; .
Alpi [Search on AGR]
Rattus norvegicus Enables alkaline phosphatase activity; metal ion binding activity; and protein homodimerization activity. Predicted to act upstream of or within cellular response to BMP stimulus. Located in external side of plasma membrane. Human ortholog(s) of this gene implicated in inflammatory bowel disease. Orthologous to several human genes including ALPI (alkaline phosphatase, intestinal); PARTICIPATES IN folate metabolic pathway; INTERACTS WITH 2,4,6-trinitrobenzenesulfonic acid; 3,7-dihydropurine-6-thione; actinomycin D.
Crtap [Search on AGR]
Homo sapiens The protein encoded by this gene is similar to the chicken and mouse CRTAP genes. The encoded protein is a scaffolding protein that may influence the activity of at least one member of the cytohesin/ARNO family in response to specific cellular stimuli. Defects in this gene are associated with osteogenesis imperfecta, a connective tissue disorder characterized by bone fragility and low bone mass. [provided by RefSeq, Jul 2008]