JP

Drosophila melanogaster

junctophilin (jp) belongs to a gene family encoding proteins anchored to the endoplasmic reticulum through a transmembrane region. The product of jp contributes to the formation and maintenance of junctional membrane complexes. It serves as a physical bridge between the plasma membrane and the endoplasmic reticulum in excitable cells, allowing the functional crosstalk between ion channels. It is necessary for calcium signalling in muscle contraction and neuronal communication.

Gena135

Mus musculus

PHENOTYPE: Mice carrying this mutation have an abnormal gait (hunched, jerky, darting), tail rattle, evidence of aggression in arena, vigourous touch escape response and tachycardia. [provided by MGI curators]