Piezo2

Homo sapiens

The protein encoded by this gene contains more than thirty transmembrane domains and likely functions as part of mechanically-activated (MA) cation channels. These channels serve to connect mechanical forces to biological signals. The encoded protein quickly adapts MA currents in somatosensory neurons. Defects in this gene are a cause of type 5 distal arthrogryposis. Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014]

Ltw6

Mus musculus

PHENOTYPE: One of many loci showing variation in liver cytosol polypeptides detected by high resolution 2D electrophoresis. Allele a is present in most strains; allele b is found in strains SWR/J, BUB, PL, and MA/My. [provided by MGI curators]

Gpt

Mus musculus

PHENOTYPE: Electrophoretic variants are detected in C57BL/6, BALB/c and DBA/2 (a allele); in MA/J and NZB/Bl (b allele). M. m. molossinus and M. m. castaneus have either the b or c allele. In liver, GPT1 activity rises dramatically at 12-19 days to adult levels. [provided by MGI curators]

Ly11

Mus musculus

PHENOTYPE: This locus controls an antigen on T-cell subpopulations. The a allele determines absence of Ly11.2 antigen in A/J, BALB/c, C3H/DiSn, CE, NZB, CBA/J and SWR. The b allele determines antigen presence in C57 strains, AKR, C58, DBA/2, SJL, 129, PL and MA/My. [provided by MGI curators]

Ly9

Mus musculus

PHENOTYPE: This locus controls an antigen on thymocytes, lymphocytes and bone marrow cells. The a allele determines Ly9.1 antigen in A/J, 129/Re, BALB/c and C3H/He; the b allele determines antigen Ly9.2 in the C57 family of strains, HTI/Go, MA/My, F/St and C58/Lw. Null mutants are viable, healthy and fertile. [provided by MGI curators]

Klrb1c

Mus musculus

PHENOTYPE: This locus controls an antigen on natural killer cells. The a allele determines the Nk1.1 antigen in strains CE, C57BL/6, C57BR/cd, C57L, C58, DBA/1, MA/My, NZB, SJL, SM and B10.D2. The b allele determines the Nk1.2 antigen in strains CBA/J, BALB/c, C3H/He, A/J, DBA/2, LP and 129. [provided by MGI curators]

Pnma5

Homo sapiens

This gene encodes a member of the paraneoplastic Ma antigen protein family. These proteins have been implicated in the development of paraneoplastic disorders resulting from an immune response directed against them. Paraneoplastic disorders are the result of an abnormal immune response to a tumor. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Oct 2011]

Jt1

Mus musculus

PHENOTYPE: AKR/J, C57BL/10, CBA/J, C3H/HeJ, C58/J, MA/My, MRL/Mp, RF/J, and B10.A(5R) strains carry the dominant b allele that allows expression of I-Jk antigen when in combination with H2k. CE/J and B10.A(3R) carry the a allele that does not allow expression of I-Jk in combination with H2k. [provided by MGI curators]

GV1

Mus musculus

PHENOTYPE: Gv1 and Gv2 control GIX antigen on thymocytes of mice with positive alleles at both loci. Allele a (presence of GIX) is seen in 129, CE, AKR, SJL, DBA/2, C3H/An, 101, C58, A and I; allele b (absence) in C57BL strains, BALB/c, CBA/J, RF/J, MA/J and SWR. Heterozygotes have half the amount of antigen. [provided by MGI curators]

Eed

Homo sapiens

This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein interacts with enhancer of zeste 2, the cytoplasmic tail of integrin beta7, immunodeficiency virus type 1 (HIV-1) MA protein, and histone deacetylase proteins. This protein mediates repression of gene activity through histone deacetylation, and may act as a specific regulator of integrin function. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]