M05D6.2

Caenorhabditis elegans

Predicted to be involved in signal transduction. Is an ortholog of human TCP11 (t-complex 11); TCP11L1 (t-complex 11 like 1); and TCP11L2 (t-complex 11 like 2).

mam-1

Caenorhabditis elegans

Predicted to enable transmembrane signaling receptor activity. Predicted to be involved in regulation of T cell activation and regulation of T cell migration. Predicted to be located in membrane.

C35B8.3

Caenorhabditis elegans

Predicted to be located in mitochondrion. Is an ortholog of human TCAIM (T cell activation inhibitor, mitochondrial).

atx-3

Caenorhabditis elegans

Enables cysteine-type deubiquitinase activity. Involved in chemical synaptic transmission. Located in cytoplasm and nucleus. Expressed in coelomocyte; head; somatic nervous system; and tail neurons. Used to study Machado-Joseph disease. Human ortholog(s) of this gene implicated in Machado-Joseph disease and late onset Parkinson's disease. Is an ortholog of human ATXN3 (ataxin 3) and ATXN3L (ataxin 3 like).

Atxn3

Homo sapiens

Machado-Joseph disease, also known as spinocerebellar ataxia-3, is an autosomal dominant neurologic disorder. The protein encoded by this gene contains (CAG)n repeats in the coding region, and the expansion of these repeats from the normal 12-44 to 52-86 is one cause of Machado-Joseph disease. There is a negative correlation between the age of onset and CAG repeat numbers. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2016]

C38H2.2

Caenorhabditis elegans

Predicted to enable glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity. Predicted to be involved in protein glycosylation. Predicted to be located in membrane. Expressed in several structures, including tail. Is an ortholog of human C1GALT1 (core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1).

tbx-40

Caenorhabditis elegans

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell fate specification and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of chromatin. Expressed in phasmid neurons. Human ortholog(s) of this gene implicated in Abruzzo-Erickson syndrome; X-linked cleft palate with or without ankyloglossia; and bone disease (multiple). Is an ortholog of several human genes including TBX15 (T-box transcription factor 15); TBX4 (T-box transcription factor 4); and TBX6 (T-box transcription factor 6).

tbx-9

Caenorhabditis elegans

Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in embryonic body morphogenesis. Located in nucleus. Expressed in several structures, including ABarpa; Eal; Ear; Epl; and Epr. Human ortholog(s) of this gene implicated in several diseases, including Holt-Oram syndrome; asthma, nasal polyps, and aspirin intolerance; and malaria. Is an ortholog of several human genes including EOMES (eomesodermin); TBR1 (T-box brain transcription factor 1); and TBX5 (T-box transcription factor 5).

cct-1

Caenorhabditis elegans

Predicted to enable unfolded protein binding activity. Predicted to be involved in protein folding. Located in nucleus. Part of chaperonin-containing T-complex. Expressed in nerve ring and in male. Is an ortholog of human TCP1 (t-complex 1).

I-t

Drosophila melanogaster

inhibitor-t (I-t) encodes a protein phosphatase inhibitor.