Abdominal B (Abd-B) is one of the three hox genes of the bithorax complex. The product of Abd-B specifies the identity of the posterior abdominal segments, the external genitalia and the gonads. It is also involved in regulating the post-mating-response.
abdominal A (abd-A) encodes a homeobox-containing transcription factor component of the bithorax complex. It contributes to the developmental fate of embryonic segments.
Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in several processes, including cell differentiation; nematode male tail tip morphogenesis; and regulation of transcription by RNA polymerase II. Located in nucleus. Expressed in several structures, including neurons; non-striated muscle; ray precursor cell; rectal epithelial cell; and somatic nervous system. Is an ortholog of human HOXA7 (homeobox A7).
Enables sequence-specific DNA binding activity. Involved in several processes, including nematode male tail tip morphogenesis; pattern specification process; and positive regulation of miRNA transcription. Located in nucleus. Expressed in head muscle; intestine; linker cell; somatic nervous system; and tail. Is an ortholog of several human genes including HOXA9 (homeobox A9); HOXB9 (homeobox B9); and HOXC10 (homeobox C10).
Motif 1 Binding Protein (M1BP) encodes a transcription pausing factor. It regulates gene transcription via interaction with the Hox proteins encoded by abd-A and Ubx. It contributes to the development of ovarian follicle cells.
Protein of unknown function; deletion mutant shows strong genetic interaction with cdc28-as1 mutant in the presence of 1-NM-PP1; DCV1 has a paralog, YOL019W, that arose from the whole genome duplication
PHENOTYPE: A knock-in allele encoding a derivative of the human red cone pigment results in hemizygous male and homozygous female mice with a ~45-nm red shift in retinal sensitivity; heterozygous females show significant changes in the chromatic sensitivities of retinal ganglion cells. [provided by MGI curators]
Predicted to enable protein phosphatase inhibitor activity. Involved in several processes, including centrosome cycle; chromosome separation; and regulation of centrosome duplication. Is an ortholog of human PPP1R2 (protein phosphatase 1 regulatory inhibitor subunit 2) and PPP1R2B (PPP1R2 family member B).
This gene is a member of the kelch-like family. The encoded protein contains a BACK domain, a BTB/POZ domain, and 5 Kelch repeats. This protein is thought to function in skeletal muscle development and maintenance. Mutations in this gene have been associated with nemaline myopathy (NM), a rare congenital muscle disorder. [provided by RefSeq, Mar 2015]
This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of leukemia, prostate cancer and lung cancer. [provided by RefSeq, Jul 2008]