mex-6

Caenorhabditis elegans

Enables mRNA 3'-UTR binding activity; protein domain specific binding activity; and protein kinase binding activity. Involved in regulation of protein localization. Located in P granule. Expressed in AB; ABa; ABp; and germ line.

cwp-5

Caenorhabditis elegans

Involved in neuronal signal transduction and response to hermaphrodite contact. Located in cell body; dendrite; and non-motile cilium. Expressed in CEM; HOB; and ray neuron type B.

mex-5

Caenorhabditis elegans

Enables RNA binding activity; protein domain specific binding activity; and protein kinase binding activity. Involved in regulation of protein localization. Located in P granule and centrosome. Expressed in germ line; head muscle; head neurons; intestine; and somatic nervous system.

pph-5

Caenorhabditis elegans

Enables Hsp90 protein binding activity and phosphoprotein phosphatase activity. Involved in negative regulation of exocytosis and protein localization to organelle. Located in cytoplasm; mitotic spindle; and protein-containing complex. Expressed in several structures, including touch receptor neurons. Is an ortholog of human PPP5C (protein phosphatase 5 catalytic subunit).

lex-1

Caenorhabditis elegans

Predicted to enable ATP hydrolysis activity; chromatin binding activity; and histone binding activity. Involved in regulation of heterochromatin formation. Predicted to be located in nucleus. Is an ortholog of human ATAD2 (ATPase family AAA domain containing 2) and ATAD2B (ATPase family AAA domain containing 2B).

daf-11

Caenorhabditis elegans

Predicted to enable adenylate cyclase activity; guanylate cyclase activity; and peptide receptor activity. Involved in several processes, including cellular response to cGMP; determination of adult lifespan; and signal transduction. Located in dendrite; neuronal cell body; and non-motile cilium. Expressed in ADLL; ADLR; ASHL; and ASHR.

alg-2

Caenorhabditis elegans

Enables RNA binding activity and RNA endonuclease activity. Involved in embryo development; nematode larval development; and regulatory ncRNA-mediated gene silencing. Located in cytoplasm. Part of RISC complex. Expressed in several structures, including gonad; hypodermis; neurons; somatic cell; and ventral nerve cord. Human ortholog(s) of this gene implicated in alcohol dependence and glaucoma. Is an ortholog of human AGO2 (argonaute RISC catalytic component 2).

lin-61

Caenorhabditis elegans

Predicted to enable chromatin binding activity and methylated histone binding activity. Involved in vulval development. Located in nucleus. Part of chromatin. Expressed widely. Is an ortholog of human L3MBTL2 (L3MBTL histone methyl-lysine binding protein 2) and MBTD1 (mbt domain containing 1).

isw-1

Caenorhabditis elegans

Predicted to enable ATP-dependent activity, acting on DNA and DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II and positive regulation of vulval development. Part of chromatin. Expressed in several structures, including head. Is an ortholog of human SMARCA1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1).

tmc-1

Caenorhabditis elegans

Enables sodium channel activity. Involved in detection of stimulus involved in sensory perception; monoatomic ion transmembrane transport; and sensory perception of chemical stimulus. Located in neuronal cell body; non-motile cilium; and plasma membrane. Expressed in body wall musculature; neurons; and in male. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 36; autosomal recessive nonsyndromic deafness 7; and sensorineural hearing loss. Is an ortholog of human TMC3 (transmembrane channel like 3).