rhea

Drosophila melanogaster

rhea (rhea) encodes fly talin, a large adaptor protein that is essential for all adhesive functions of integrins. It also has at least one role independent of integrins: repressing shg transcription in follicle cells.

wech

Drosophila melanogaster

wech (wech) encodes a member of the RBCC/TRIM family of cytoplasmic multidomain proteins. It is a regulator of integrin-mediated adhesion. It interacts with the products of rhea and Ilk, which are components of the integrin-cytoskeleton link.

Vinc

Drosophila melanogaster

Vinculin (Vinc) encodes a key mechanoeffector of cell-cell and cell-extracellular matrix adhesion. It binds to the products of rhea and alpha-Cat, when they are stretched by force, and links them to actin. Vinc mutant flies are viable and fertile although mild defects have been documented in muscle attachment and heart function.