F27D9.7

Caenorhabditis elegans

Predicted to enable metalloendopeptidase activity. Predicted to be involved in membrane protein ectodomain proteolysis. Predicted to be located in membrane. Is an ortholog of human ADAMDEC1 (ADAM like decysin 1).

tag-275

Caenorhabditis elegans

Predicted to enable metal ion binding activity and metalloendopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in membrane. Is an ortholog of human ADAMDEC1 (ADAM like decysin 1).

adm-2

Caenorhabditis elegans

Predicted to enable metalloendopeptidase activity. Predicted to be involved in membrane protein ectodomain proteolysis. Predicted to be located in endosome membrane; lysosomal membrane; and plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); endocrine gland cancer (multiple); and lung disease (multiple). Is an ortholog of human ADAM19 (ADAM metallopeptidase domain 19) and ADAM33 (ADAM metallopeptidase domain 33).

adm-4

Caenorhabditis elegans

Predicted to enable metalloendopeptidase activity. Involved in Notch signaling pathway and cell fate specification. Predicted to be located in plasma membrane. Expressed in gonad; hypodermis; tail; and vulva. Human ortholog(s) of this gene implicated in Alzheimer's disease; inflammatory bowel disease; renal fibrosis; and type 2 diabetes mellitus. Is an ortholog of human ADAM17 (ADAM metallopeptidase domain 17).

TMUE_2000010475

Trichuris muris

Is predicted to encode a protein with the following domains: ADAM, cysteine-rich domain and ADAM cysteine-rich.

unc-71

Caenorhabditis elegans

Predicted to enable metalloendopeptidase activity. Predicted to be involved in membrane protein ectodomain proteolysis. Located in membrane. Expressed in several structures, including buccal cavity; excretory system; nerve ring; neuronal sheath cell; and neurons. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 61. Is an ortholog of human ADAM22 (ADAM metallopeptidase domain 22) and ADAM23 (ADAM metallopeptidase domain 23).

sup-17

Caenorhabditis elegans

Predicted to enable metalloendopeptidase activity. Involved in several processes, including nematode male tail tip morphogenesis; positive regulation of transforming growth factor beta receptor signaling pathway; and vulval development. Located in cytoplasmic vesicle membrane and plasma membrane. Expressed in M lineage cell; hypodermis; intestinal cell; spermatheca; and vulva. Human ortholog(s) of this gene implicated in Alzheimer's disease 18; colorectal cancer; and reticulate acropigmentation of Kitamura. Is an ortholog of human ADAM10 (ADAM metallopeptidase domain 10).

kuz

Drosophila melanogaster

kuzbanian (kuz) encodes an ADAM metalloendopeptidase that regulates activation of the receptors encoded by N and robo1 by cleavage.

Kul

Drosophila melanogaster

Kuzbanian-like (Kul) encodes an ADAM metalloprotease involved in regulation of the Notch signaling pathway by cleaving the product of Delta.

Adam10

Homo sapiens

Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin. Alternate splicing results in multiple transcript variants encoding different proteins that may undergo similar processing. [provided by RefSeq, Feb 2016]