- ADGRE4P [Search on AGR]
Homo sapiens This gene is a member of the EGF-TM7 receptor gene family which is thought to play a role in leukocyte adhesion and migration. In other vertebrates, including nonhuman primates, this gene encodes a protein containing N-terminal EGF domains and a C-terminal transmembrane domain. Sequence evidence for the human gene, however, indicates nucleotide deletion in the genomic sequence would result in frameshift and early termination of translation. A protein expressed by this gene would be soluble rather than expressed on the cell surface. As the encoded protein has not been detected, this gene may represent a transcribed pseudogene. [provided by RefSeq, Aug 2008]
- fid [Search on AGR]
Drosophila melanogaster fire dancer (fid) encodes a protein involved in heat resistance.
- Fie [Search on AGR]
Drosophila melanogaster Fire exit (Fie) is expressed in some peripheral glia cells and encodes a transmembrane protein that may be involved in intracellular transport during glial development.
- Insyn1 [Search on AGR]
Mus musculus PHENOTYPE: Mice homozygous for a knock-out allele exhibit elevated neuronal firing patterns in the hippocampus and deficits in fear conditioning memory. [provided by MGI curators]
- Mtnr1a [Search on AGR]
Mus musculus PHENOTYPE: Mice homozygous for disruptions in this gene are essentially normal, with normal circadian functions. In vitro studies report the absence of inhibitory effects of melatonin on suprachiasma neuronal firing. [provided by MGI curators]
- Rem2 [Search on AGR]
Mus musculus PHENOTYPE: Mice homozygous for a knock-out allele exhibit strain-specific impaired viability and fertility as well as altered intrinsic excitability and spontaneous firing in visual circuits. [provided by MGI curators]
- qsm [Search on AGR]
Drosophila melanogaster quasimodo (qsm) encodes a light-responsive factor of the circadian clock. It controls the rhythmic firing of clock neurons via the K+ channel and the Na+ K+ Cl- cotransporter encoded by Shaw and NKCC respectively.
- SLD7 [Search on AGR]
Saccharomyces cerevisiae Protein with a role in chromosomal DNA replication; interacts with Sld3p and reduces its affinity for Cdc45p; deletion mutant has aberrant mitochondria; ortholog of human MTBP, which is a DNA replication origin firing factor
- Lamb1 [Search on AGR]
Mus musculus PHENOTYPE: Embryos homozygous for a gene trapped allele lack basement membranes and fail to survive past E5.5. Mice heterozygous for a spontaneous mutation exhibit dystonis with impaired neuron firing. [provided by MGI curators]
- Adra2a [Search on AGR]
Mus musculus PHENOTYPE: Mice homozygous for targeted mutations that inactivate the gene fail to produce hypotensive responsiveness to alpha2AR agonists, including failure to inhibit voltage-gated Ca2+ currents and spontaneous neuronal firing. [provided by MGI curators]