lymphoplasmacytic lymphoma

A B-cell lymphoma characterized by the accumulation of monoclonal cells in the bone marrow and peripheral lymphoid tissues, and associated with the production of serum immunoglobulin M (IgM) monoclonal protein.

Burkitt lymphoma

A mature B-cell neoplasm of B-cells found in the germinal center.

lambda 5 deficiency

A B cell deficiency that has_material_basis_in mutations in the IGLL1 gene. Lambda 5 mutations can cause a block in B cell development at the transition between the pro-B cell and the pre-B cell stage.

B-lymphoblastic leukemia/lymphoma with hypodiploidy

A B-lymphoblastic leukemia/lymphoma that is composed of B-lymphoblasts which contain less than 46 chromosomes.

splenic marginal zone lymphoma

A marginal zone B-cell lymphocyte located_in the spleen comprised of B-cells in place of white pulp.

diffuse large B-cell lymphoma

A large B-cell lymphoma that is consisting of medium-sized to large B cells with a diffuse growth pattern.

B-lymphoblastic leukemia/lymphoma with hyperdiploidy

A B-lymphoblastic leukemia/lymphoma that is composed of B-lymphoblasts which contain more than 50 and usually less than 66 chromosomes.

follicular lymphoma

A B-cell lymphoma that is characterized as an indolent non-Hodgkin's lymphoma and has_material_basis_in follicle center B-cells (centrocytes and centroblasts).

primary mediastinal B-cell lymphoma

A large B-cell lymphoma that is is characterized by a diffuse proliferation of medium to large B-cells associated with sclerosis.

CD40 ligand deficiency

A combined T cell and B cell immunodeficiency that is a X-linked immunodeficiency with hyperimmunoglobulin M (XHIM) affecting isotype switching and is caused by the absence of CD40 ligand which is normally expressed on activated CD4+ T cells. Individuals with this mutation are unable to switch from IgM to IgG, IgA and IgE.