DNA ligase IV deficiency

A combined T cell and B cell immunodeficiency that has_material_basis_in a mutation in the LIG4 gene, a DNA ligase, encoding a protein essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). Patients present with immunodeficiency and developmental and growth delay.

Burkitt lymphoma

A mature B-cell neoplasm of B-cells found in the germinal center.

lambda 5 deficiency

A B cell deficiency that has_material_basis_in mutations in the IGLL1 gene. Lambda 5 mutations can cause a block in B cell development at the transition between the pro-B cell and the pre-B cell stage.

B-lymphoblastic leukemia/lymphoma with hypodiploidy

A B-lymphoblastic leukemia/lymphoma that is composed of B-lymphoblasts which contain less than 46 chromosomes.

splenic marginal zone lymphoma

A marginal zone B-cell lymphocyte located_in the spleen comprised of B-cells in place of white pulp.

diffuse large B-cell lymphoma

A large B-cell lymphoma that is consisting of medium-sized to large B cells with a diffuse growth pattern.

B-lymphoblastic leukemia/lymphoma with hyperdiploidy

A B-lymphoblastic leukemia/lymphoma that is composed of B-lymphoblasts which contain more than 50 and usually less than 66 chromosomes.

follicular lymphoma

A B-cell lymphoma that is characterized as an indolent non-Hodgkin's lymphoma and has_material_basis_in follicle center B-cells (centrocytes and centroblasts).

primary mediastinal B-cell lymphoma

A large B-cell lymphoma that is is characterized by a diffuse proliferation of medium to large B-cells associated with sclerosis.

large B-cell lymphoma

A B-cell lymphoma that is characterized by large lymphoid cells of the B-cell lineage that by definition form sheets or clusters.