Gene Ontology Annotation (GOA) Program at the UniProt Knowledgebase (UniProtKB)

The UniProt GO annotation program aims to provide high-quality Gene Ontology (GO) annotations to proteins in the UniProt Knowledgebase (UniProtKB). The assignment of GO terms to UniProt records is an integral part of UniProt biocuration.

Gene Ontology annotation performed by IntAct curators.

Gene Ontology annotations to GO Molecular Function term GO:0005515 (protein binding) and its children performed by IntAct curators as part of their molecular interaction curation.

Gene Ontology annotation inferred by sequence similarity to mammalian gene products.

GO annotations with HGNC as source are made on the basis of sequence similarity between vertebrate and invertebrate gene products.

A systems toxicology approach reveals the Wnt-MAPK crosstalk pathway mediated reproductive failure in Caenorhabditis elegans exposed to graphene oxide (GO) but not to reduced graphene oxide (rGO).

A systems toxicology approach reveals the Wnt-MAPK crosstalk pathway mediated reproductive failure in Caenorhabditis elegans exposed to graphene oxide (GO) but not to reduced graphene oxide (rGO).

InterProScan a tools for mining Protein signature database.

InterProScan is a tool that combines different protein signature recognition methods native to the InterPro member databases into one resource with look up of corresponding InterPro and GO annotation.

Gene Ontology annotation generated from asserted links between terms in the different ontologies of GO: Biological Process, Molecular Function, and Cellular Component.

Annotations automatically inferred from asserted links between the different ontologies of GO. These annotations are generated from part_of relationships between Molecular Function and Biological Process and regulates relationships within both Molecular Function and Biological Process and between Biological Process and Molecular Function.