ihIs34

Caenorhabditis elegans

[yap-1::gfp; lin-15(+)]

ihIs35

Caenorhabditis elegans

[yap-1::gfp; lin-15(+)]

RT3574

Caenorhabditis elegans

yap-1

Caenorhabditis elegans

Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and protein kinase binding activity. Involved in establishment of cell polarity and positive regulation of transcription by RNA polymerase II. Located in axoneme; ciliary base; and nucleus. Part of RNA polymerase II transcription regulator complex. Expressed in several structures, including excretory system; hermaphrodite gonad; pharyngeal muscle cell; tail hypodermis; and vulva. Human ortholog(s) of this gene implicated in colorectal cancer and uveal coloboma-cleft lip and palate-intellectual disability. Is an ortholog of human WWTR1 (WW domain containing transcription regulator 1) and YAP1 (Yes1 associated transcriptional regulator).

ftt-2

Caenorhabditis elegans

Enables DNA-binding transcription factor binding activity. Involved in cytoplasmic sequestering of protein; dauer larval development; and negative regulation of protein import into nucleus. Located in cytoplasm and nucleus. Expressed in several structures, including C; E; Psub3; gonad; and intestine. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); ovarian cancer; and urinary bladder cancer. Is an ortholog of human YWHAB (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta) and YWHAZ (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta).

rme-1

Caenorhabditis elegans

Enables ATP hydrolysis activity and protein domain specific binding activity. Involved in several processes, including endocytic recycling; lipid tube assembly involved in organelle fission; and necroptotic process. Located in recycling endosome membrane. Expressed in coelomocyte; germ line; gonad; intestine; and pharynx. Is an ortholog of human EHD1 (EH domain containing 1).

wts-1

Caenorhabditis elegans

Enables protein serine/threonine kinase activity and transcription coactivator binding activity. Involved in several processes, including apical protein localization; negative regulation of protein import into nucleus; and post-embryonic development. Located in apical plasma membrane and cytoplasm. Expressed in several structures, including excretory canal; hypodermis; intestine; spermatheca; and vulva. Human ortholog(s) of this gene implicated in colorectal cancer. Is an ortholog of human LATS1 (large tumor suppressor kinase 1).

egl-44

Caenorhabditis elegans

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; RNA polymerase II-specific DNA-binding transcription factor binding activity; and transcription coactivator binding activity. Involved in several processes, including generation of neurons; positive regulation of exit from mitosis; and regulation of transcription by RNA polymerase II. Located in nucleus. Part of RNA polymerase II transcription regulator complex. Expressed in several structures, including anterior hypodermis; body wall musculature; ganglia; neurons; and pharynx. Human ortholog(s) of this gene implicated in Sveinsson chorioretinal atrophy. Is an ortholog of human TEAD2 (TEA domain transcription factor 2) and TEAD4 (TEA domain transcription factor 4).

ehbp-1

Caenorhabditis elegans

Enables small GTPase binding activity. Involved in endocytic recycling; protein secretion; and receptor recycling. Located in early endosome membrane and recycling endosome membrane. Expressed in several structures, including body wall musculature; hermaphrodite gonad; intestine; nerve ring; and pharynx. Is an ortholog of human EHBP1 (EH domain binding protein 1).

arf-6

Caenorhabditis elegans

Predicted to enable GTP binding activity and GTPase activity. Involved in negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process; positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process; and positive regulation of endosome to plasma membrane protein transport. Located in basolateral plasma membrane; cytoplasmic side of apical plasma membrane; and recycling endosome membrane. Expressed in several structures, including excretory cell; intestine; pharyngeal muscle cell; ventral nerve cord; and vulva. Is an ortholog of human ARF6 (ADP ribosylation factor 6).