WH497

Caenorhabditis elegans

CZ14748

Caenorhabditis elegans

ckc-1

Caenorhabditis elegans

Predicted to enable ethanolamine kinase activity. Predicted to be involved in phosphatidylethanolamine biosynthetic process. Predicted to be located in cytoplasm. Is an ortholog of human ETNK2 (ethanolamine kinase 2).

ghi-1

Caenorhabditis elegans

Predicted to enable lipid binding activity.

pcaf-1

Caenorhabditis elegans

Predicted to enable histone H3 acetyltransferase activity. Predicted to be involved in chromatin remodeling and positive regulation of transcription by RNA polymerase II. Predicted to be located in centrosome and nucleus. Predicted to be part of ATAC complex. Human ortholog(s) of this gene implicated in breast cancer; carcinoma (multiple); and rheumatoid arthritis. Is an ortholog of human KAT2A (lysine acetyltransferase 2A).

sul-1

Caenorhabditis elegans

Enables heparan sulfate 6-O-sulfotransferase activity. Involved in heparan sulfate proteoglycan biosynthetic process, enzymatic modification. Predicted to be located in Golgi stack; cell surface; and endoplasmic reticulum. Is an ortholog of human SULF1 (sulfatase 1) and SULF2 (sulfatase 2).

fcho-1

Caenorhabditis elegans

Involved in clathrin-dependent endocytosis. Located in plasma membrane. Expressed in amphid neurons; hypodermis; intestine; pharyngeal cell; and rectal gland cell. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Is an ortholog of human FCHO2 (FCH and mu domain containing endocytic adaptor 2).

tol-1

Caenorhabditis elegans

Predicted to enable signaling receptor activity. Involved in defense response to Gram-negative bacterium and embryo development. Predicted to be located in extracellular matrix and extracellular space. Expressed in neurons. Is an ortholog of several human genes including CHAD (chondroadherin); ELFN2 (extracellular leucine rich repeat and fibronectin type III domain containing 2); and TRIL (TLR4 interactor with leucine rich repeats).

rbf-1

Caenorhabditis elegans

Predicted to enable metal ion binding activity. Involved in dense core granule exocytosis and positive regulation of locomotion. Located in synaptic vesicle. Expressed in dorsal nerve cord; nerve ring; neurons; and ventral nerve cord. Is an ortholog of human RPH3A (rabphilin 3A).

fbxl-1

Caenorhabditis elegans

Involved in several processes, including dauer entry; defecation rhythm; and regulation of defecation rhythm. Located in perikaryon and plasma membrane bounded cell projection. Is an ortholog of human FBXL2 (F-box and leucine rich repeat protein 2) and FBXL20 (F-box and leucine rich repeat protein 20).