gene: chd-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable several functions, including ATP hydrolysis activity; ATP-dependent activity, acting on DNA; and histone binding activity. Involved in cell fate determination; negative regulation of Ras protein signal transduction; and negative regulation of vulval development. Predicted to be located in nucleus. Predicted to be part of NuRD complex. Expressed in several structures, including distal tip cell; pharynx; ventral nerve cord; vulva; and vulval precursor cell. Human ortholog(s) of this gene implicated in several diseases, including Sifrim-Hitz-Weiss syndrome; gastrointestinal system cancer (multiple); and lung adenocarcinoma. Is an ortholog of human CHD3 (chromodomain helicase DNA binding protein 3).
gene: let-418 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Contributes to RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in embryonic digestive tract morphogenesis; negative regulation of transcription by RNA polymerase II; and negative regulation of vulval development. Part of RNA polymerase II transcription repressor complex. Expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; P8.p hermaphrodite; gonad; and somatic nervous system. Human ortholog(s) of this gene implicated in several diseases, including Sifrim-Hitz-Weiss syndrome; gastrointestinal system cancer (multiple); and lung adenocarcinoma. Is an ortholog of human CHD3 (chromodomain helicase DNA binding protein 3).