gene: sel-8 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables DNA-binding transcription factor binding activity; Notch binding activity; and transcription coactivator activity. Involved in several processes, including Notch signaling pathway; positive regulation of stem cell proliferation; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of RNA polymerase II transcription regulator complex. Expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; P5.p hermaphrodite; P8.p hermaphrodite; and neurons.
gene: tbb-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Involved in meiotic spindle organization. Located in spindle microtubule. Expressed in several structures, including germ line; gonad; oocyte; tail; and touch receptor neurons. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations 1 and congenital fibrosis of the extraocular muscles 3A. Is an ortholog of several human genes including TUBB3 (tubulin beta 3 class III); TUBB6 (tubulin beta 6 class V); and TUBB8B (tubulin beta 8B).