pot-1

Caenorhabditis elegans

Enables C-rich strand telomeric DNA binding activity. Involved in negative regulation of telomere maintenance via telomere lengthening and telomere maintenance. Located in chromosome, telomeric region.

W10D9.3

Caenorhabditis elegans

Enriched in Caapa; body wall muscle cell; germ line; intestine; and sensory neurons based on tiling array; RNA-seq; and single-cell RNA-seq studies. Is affected by several genes including cyc-1; isp-1; and mrps-5 based on microarray and RNA-seq studies. Is affected by ten chemicals including rotenone; Cry5B; and stavudine based on RNA-seq and microarray studies. Is predicted to encode a protein with the following domains: MKRN2 opposite strand protein-like, C-terminal; MKRN2 opposite strand protein-like; and DUF4796 C-terminal. Is an ortholog of human MKRN2OS (MKRN2 opposite strand).

T02C1.2

Caenorhabditis elegans

Predicted to enable nucleosome binding activity and ubiquitin-protein transferase activity. Predicted to be involved in double-strand break repair. Predicted to be located in nucleus and site of double-strand break. Is an ortholog of human RNF169 (ring finger protein 169).

C44C10.10

Caenorhabditis elegans

Predicted to enable ATP hydrolysis activity. Predicted to be involved in double-strand break repair. Predicted to be located in membrane.

D1007.8

Caenorhabditis elegans

Predicted to enable single-stranded DNA binding activity and telomeric DNA binding activity. Predicted to be involved in DNA replication; double-strand break repair via homologous recombination; and nucleotide-excision repair. Predicted to be located in chromosome, telomeric region and site of double-strand break. Predicted to be part of DNA replication factor A complex.

cosa-1

Caenorhabditis elegans

Involved in reciprocal meiotic recombination. Located in site of double-strand break. Is an ortholog of human CNTD1 (cyclin N-terminal domain containing 1).

C23H4.6

Caenorhabditis elegans

Predicted to enable damaged DNA binding activity and single-stranded DNA binding activity. Predicted to be involved in double-strand break repair via homologous recombination. Predicted to be located in nucleus and site of double-strand break. Predicted to be part of Smc5-Smc6 complex. Expressed in tail. Is an ortholog of human SMC6 (structural maintenance of chromosomes 6).

pot-2

Caenorhabditis elegans

Enables G-rich strand telomeric DNA binding activity. Involved in negative regulation of telomere maintenance via telomere lengthening and telomere maintenance. Located in chromosome, telomeric region.

sld-5

Caenorhabditis elegans

Predicted to be involved in double-strand break repair via break-induced replication. Located in nucleus. Is an ortholog of human GINS4 (GINS complex subunit 4).

rad-50

Caenorhabditis elegans

Predicted to enable G-quadruplex DNA binding activity; double-stranded telomeric DNA binding activity; and single-stranded telomeric DNA binding activity. Predicted to be involved in chromosome organization and double-strand break repair. Predicted to be located in condensed nuclear chromosome. Predicted to be part of Mre11 complex. Human ortholog(s) of this gene implicated in invasive ductal carcinoma and transitional cell carcinoma. Is an ortholog of human RAD50 (RAD50 double strand break repair protein).