Enables BH domain binding activity. Involved in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator and positive regulation of apoptotic process.
Enables several functions, including BH domain binding activity; peptidase activator activity; and small molecule binding activity. Involved in several processes, including muscle cell cellular homeostasis; positive regulation of synapse pruning; and regulation of apoptotic process. Located in several cellular components, including cytoplasm; membrane; and nucleus. Part of caspase complex. Expressed in several structures, including germ line. Human ortholog(s) of this gene implicated in Parkinson's disease; lung non-small cell carcinoma; and pancreatic cancer. Is an ortholog of human APAF1 (apoptotic peptidase activating factor 1).
The raw data was normalized and t-statics were computed using R and Bioconductor with the affy package and Benjamini-Hoch-berg (BH) correction method for multiple comparisons. RNA levels that changed at least 1.5-fold with a probability of p < 0.005 after BH correction were considered significantly different in mir-35(gk262) mutants relative to wild-type.
Genes with expression level down regulated in mir-35 mutants comparing with N2.
The raw data was normalized and t-statics were computed using R and Bioconductor with the affy package and Benjamini-Hoch-berg (BH) correction method for multiple comparisons. RNA levels that changed at least 1.5-fold with a probability of p < 0.005 after BH correction were considered significantly different in mir-35(gk262) mutants relative to wild-type.
Genes with expression level up regulated in mir-35 mutants comparing with N2.
Author used empirical Bayes fitting in limma with multiple hypothesis correction method BH, and considered genes with a P-value < 0.05 to be differentially expressed.
Genes downregulated in mdt-15(RNAi) animals comparing with control.
Author used empirical Bayes fitting in limma with multiple hypothesis correction method BH, and considered genes with a P-value < 0.05 to be differentially expressed.
Genes upregulated in mdt-15(RNAi) animals comparing with control.
FDR < 0.01, fold change > 2. Stistical analysis was performed using Benjamini-Hochberg (BH) adjustment using the MATLAB (Mathworks) function nbintest with the VarianceLink setting LocalRegression.
Transcripts that showed significantly increased expression in sid-2(mj465) animals comparing to in N2.
FDR < 0.01, fold change > 2. Stistical analysis was performed using Benjamini-Hochberg (BH) adjustment using the MATLAB (Mathworks) function nbintest with the VarianceLink setting LocalRegression.
Transcripts that showed significantly decreased expression in sid-2(mj465) animals comparing to in N2.
The limma package was used to calculate differential expression using the limma linear model fit, eBayes smoothing of standard errors, and Benjamini-hochberg(Bh) multiple test correction with a false discovery rate of 5%.
Genes with increased expression in tbx-2(bx59) comparing to N2.
The limma package was used to calculate differential expression using the limma linear model fit, eBayes smoothing of standard errors, and Benjamini-hochberg(Bh) multiple test correction with a false discovery rate of 5%.
Genes with decreased expression in tbx-2(bx59) comparing to N2.