F19C7.8

Caenorhabditis elegans

Predicted to be involved in positive regulation of protein localization to plasma membrane and skeletal muscle contraction. Human ortholog(s) of this gene implicated in Native American myopathy. Is an ortholog of human STAC (SH3 and cysteine rich domain); STAC2 (SH3 and cysteine rich domain 2); and STAC3 (SH3 and cysteine rich domain 3).

lron-8

Caenorhabditis elegans

Predicted to be located in extracellular matrix and extracellular space. Expressed in body wall musculature; head muscle; pharynx; and rectal gland cell. Human ortholog(s) of this gene implicated in several diseases, including autosomal recessive intellectual developmental disorder 64; congenital stationary night blindness 1A; and stomach cancer. Is an ortholog of several human genes including LRRN1 (leucine rich repeat neuronal 1); LRRN2 (leucine rich repeat neuronal 2); and LRRN3 (leucine rich repeat neuronal 3).

Y46E12A.3

Caenorhabditis elegans

Predicted to be involved in sensory perception of sound. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 25. Is an ortholog of human GRXCR1 (glutaredoxin and cysteine rich domain containing 1).

mlp-1

Caenorhabditis elegans

Predicted to enable metal ion binding activity. Located in striated muscle dense body. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1M and hypertrophic cardiomyopathy 12. Is an ortholog of human CSRP1 (cysteine and glycine rich protein 1); CSRP2 (cysteine and glycine rich protein 2); and CSRP3 (cysteine and glycine rich protein 3).

JU1615

Caenorhabditis elegans

swsn-7

Caenorhabditis elegans

Predicted to enable DNA binding activity. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 6 and gastrointestinal system cancer (multiple). Is an ortholog of human ARID2 (AT-rich interaction domain 2).

K10D2.8

Caenorhabditis elegans

Enriched in head mesodermal cell and in male based on RNA-seq studies. Is affected by several genes including mut-16; etr-1; and csr-1 based on microarray and RNA-seq studies. Is affected by twelve chemicals including manganese chloride; rifampin; and allantoin based on RNA-seq and microarray studies. Is predicted to encode a protein with the following domains: Leucine Rich repeat; Leucine Rich repeats (2 copies); Leucine-rich repeat; Leucine-rich repeat, typical subtype; Leucine rich repeat 4; Leucine-rich repeat domain superfamily; and Ciliary and flagellar integrity-associated protein.

lron-4

Caenorhabditis elegans

Enriched in neurons based on tiling array; RNA-seq; single-cell RNA-seq; and microarray studies. Is affected by several genes including cyc-1; nuo-6; and atfs-1 based on microarray; RNA-seq; and proteomic studies. Is affected by resveratrol based on microarray studies. Is predicted to encode a protein with the following domains: Leucine-rich repeat; Leucine-rich repeat, typical subtype; Small Leucine-Rich Proteoglycans; Leucine rich repeat; and Leucine-rich repeat domain superfamily.

lrch-1

Caenorhabditis elegans

Predicted to be involved in signal transduction. Is an ortholog of several human genes including LRCH1 (leucine rich repeats and calponin homology domain containing 1); LRCH2 (leucine rich repeats and calponin homology domain containing 2); and LRCH4 (leucine rich repeats and calponin homology domain containing 4).

ufIs6

Caenorhabditis elegans

[Pmyo-3::unc-38(V/S), Pmyo-3::unc-29(L/S), Pmyo-3::lev-1(L/S)]