Predicted to enable glutamate receptor activity and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Involved in detection of cold stimulus involved in thermoception and detection of temperature stimulus involved in sensory perception of pain. Predicted to be located in postsynaptic density membrane. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease and temporal lobe epilepsy. Is an ortholog of human GRIK3 (glutamate ionotropic receptor kainate type subunit 3) and GRIK4 (glutamate ionotropic receptor kainate type subunit 4).
Predicted to enable monoatomic ion channel activity. Predicted to be involved in monoatomic ion transmembrane transport. Located in neuronal cell body and non-motile cilium. Expressed in several structures, including excretory system; pharyngeal muscle cell; sensory neurons; ventral nerve cord; and vulva. Human ortholog(s) of this gene implicated in familial episodic pain syndrome 1. Is an ortholog of human TRPA1 (transient receptor potential cation channel subfamily A member 1).
Predicted to enable neuropeptide binding activity and neuropeptide receptor activity. Involved in regulation of muscle contraction. Predicted to be located in neuron projection and plasma membrane. Expressed in body wall musculature; chemosensory neurons; and head neurons. Human ortholog(s) of this gene implicated in hypertension. Is an ortholog of human PRLHR (prolactin releasing hormone receptor).
Enables neuropeptide receptor activity. Involved in several processes, including behavioral response to ethanol; social behavior; and thermotaxis. Located in axon; plasma membrane; and somatodendritic compartment. Expressed in excretory system; neurons; pharyngeal muscle cell; and preanal ganglion. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in hypertension. Is an ortholog of human PRLHR (prolactin releasing hormone receptor).