cat-2

Caenorhabditis elegans

Enables tyrosine 3-monooxygenase activity. Involved in several processes, including cellular response to amphetamine; dopamine biosynthetic process from tyrosine; and male mating behavior. Located in axon. Expressed in dopaminergic neurons; socket cell; and in male. Used to study several diseases, including amphetamine abuse; cocaine abuse; and nicotine dependence. Human ortholog(s) of this gene implicated in several diseases, including Parkinsonism; artery disease (multiple); and obesity. Is an ortholog of human TH (tyrosine hydroxylase).

WBPaper00056391:HT115_downregulated

Differentially regulated genes were determined on the basis of fold change (> 2) and the value of a modified Wilcoxon rank test (> 1.5). Th eWilcoxon coefficient was determined for each probe set as the smallest expression value in the condition with higher average divided by the highest expression value in the condition with lower average. Transcripts with significantly decreased expression by feeding on E. coli HT115 vs. E. coli OP50. in young adult glp-4(bn2) worms, grown on E. coli HT115 since L1 stage. Fold changes shown are normalized to the genes expression levels in E. coliOP50.

WBPaper00056391:HT115_upregulated

Differentially regulated genes were determined on the basis of fold change (> 2) and the value of a modified Wilcoxon rank test (> 1.5). Th eWilcoxon coefficient was determined for each probe set as the smallest expression value in the condition with higher average divided by the highest expression value in the condition with lower average. Transcripts with significantly increased expression by feeding on E. coli HT115 vs. E. coli OP50. in young adult glp-4(bn2) worms, grown on E. coli HT115 since L1 stage. Fold changes shown are normalized to the genes expression levels in E. coliOP50.