gene: ver-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable transmembrane receptor protein tyrosine kinase activity. Involved in nematode male tail tip morphogenesis. Predicted to be located in plasma membrane. Predicted to be part of receptor complex. Expressed in intestinal muscle; intestine; and neuronal sheath cell. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); eye disease (multiple); and hematologic cancer (multiple). Is an ortholog of several human genes including FLT1 (fms related receptor tyrosine kinase 1); FLT3 (fms related receptor tyrosine kinase 3); and FLT4 (fms related receptor tyrosine kinase 4).
gene: ztf-16 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in gonad development and positive regulation of gene expression. Located in nucleus. Expressed in accessory cell; gonad; hypodermis; and tail. Human ortholog(s) of this gene implicated in several diseases, including B-lymphoblastic leukemia/lymphoma; carcinoma (multiple); and common variable immunodeficiency 13. Is an ortholog of several human genes including IKZF1 (IKAROS family zinc finger 1); IKZF2 (IKAROS family zinc finger 2); and IKZF3 (IKAROS family zinc finger 3).
gene: ttx-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables DNA-binding transcription factor activity and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including positive regulation of transcription by RNA polymerase II; regulation of plasma membrane bounded cell projection assembly; and thermosensory behavior. Located in nucleus. Expressed in head neurons and pharyngeal cell. Human ortholog(s) of this gene implicated in panhypopituitarism and syndromic microphthalmia 5. Is an ortholog of human OTX1 (orthodenticle homeobox 1).