gene: bro-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables transcription corepressor activity. Involved in several processes, including negative regulation of transcription by RNA polymerase II; nematode male tail tip morphogenesis; and positive regulation of locomotion involved in locomotory behavior. Located in nucleus. Part of core-binding activity factor complex. Expressed in hypodermis; muscle cell; pharyngeal neurons; ray precursor cell; and uterine seam cell. Human ortholog(s) of this gene implicated in acute myelomonocytic leukemia and hepatocellular carcinoma. Is an ortholog of human CBFB (core-binding factor subunit beta).