prps-1

Caenorhabditis elegans

Predicted to enable ATP binding activity and ribose phosphate diphosphokinase activity. Predicted to be involved in 5-phosphoribose 1-diphosphate biosynthetic process and purine nucleotide biosynthetic process. Predicted to be located in cytoplasm. Predicted to be part of ribose phosphate diphosphokinase complex. Expressed in head; somatic gonad precursor; somatic nervous system; and tail. Human ortholog(s) of this gene implicated in several diseases, including Arts syndrome; X-linked deafness 1; and X-linked recessive disease (multiple). Is an ortholog of human PRPS1 (phosphoribosyl pyrophosphate synthetase 1); PRPS1L1 (phosphoribosyl pyrophosphate synthetase 1 like 1); and PRPS2 (phosphoribosyl pyrophosphate synthetase 2).

unc-30

Caenorhabditis elegans

Enables sequence-specific DNA binding activity. Involved in neuron differentiation; positive regulation of transcription by RNA polymerase II; and regulation of locomotion. Located in nucleus. Expressed in GABAergic neurons; ganglia; intestine; and ventral cord neurons. Human ortholog(s) of this gene implicated in Arts syndrome; clubfoot; and eye disease (multiple). Is an ortholog of human PITX2 (paired like homeodomain 2) and PITX3 (paired like homeodomain 3).