Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in neuron differentiation. Predicted to be located in nucleus. Expressed in head muscle; head neurons; intestine; lumbar neurons; and somatic nervous system.
Enables pore-forming activity. Involved in defense response to other organism and pore formation in membrane of another organism. Part of pore complex.
Enables sequence-specific DNA binding activity. Involved in several processes, including chordate pharyngeal muscle development; gonad morphogenesis; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Expressed in several structures, including G1; gonad; neurons; pharyngeal cell; and ventral nerve cord. Used to study cancer. Is an ortholog of human NKX2-2 (NK2 homeobox 2).
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell differentiation; regulation of transcription by RNA polymerase II; and regulation of transcription elongation by RNA polymerase II. Predicted to be located in nucleus. Expressed in head muscle; intestine; neurons; non-striated muscle; and ventral nerve cord. Human ortholog(s) of this gene implicated in choreatic disease and papillary thyroid carcinoma. Is an ortholog of human NKX2-1 (NK2 homeobox 1) and NKX2-4 (NK2 homeobox 4).
Enables identical protein binding activity. Involved in defense response to Gram-negative bacterium and defense response to Gram-positive bacterium. Located in protein-containing complex. Expressed in SDQR.
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II and regulation of neuron differentiation. Part of chromatin. Expressed in several structures, including ABalaappa; ABalaappaa; ABalaappap; ABalapapa; and M4 neuron. Human ortholog(s) of this gene implicated in several diseases, including aortic valve disease 2; congenital heart disease (multiple); and heart conduction disease (multiple). Is an ortholog of human NKX2-5 (NK2 homeobox 5).
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell differentiation and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed in I6 neuron; intestine; nerve ring; and nerve ring neurons.