sma-2

Caenorhabditis elegans

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; I-SMAD binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including male anatomical structure morphogenesis; nematode pharynx development; and regulation of anatomical structure morphogenesis. Predicted to be located in cytoplasm and nucleus. Predicted to be part of heteromeric SMAD protein complex. Expressed in head. Human ortholog(s) of this gene implicated in several diseases, including Loeys-Dietz syndrome 3; carcinoma (multiple); and reproductive organ cancer (multiple). Is an ortholog of human SMAD9 (SMAD family member 9).

daf-4

Caenorhabditis elegans

Enables BMP binding activity. Involved in several processes, including defense response to other organism; regulation of BMP signaling pathway; and regulation of anatomical structure morphogenesis. Located in plasma membrane. Expressed in several structures, including ganglia; intestine; somatic nervous system; tail hypodermis; and vulva. Used to study Marfan syndrome. Human ortholog(s) of this gene implicated in several diseases, including Loeys-Dietz syndrome 2; artery disease (multiple); and gastrointestinal system cancer (multiple). Is an ortholog of human ACVR2B (activin A receptor type 2B).