WBPaper00003173Ex3

Caenorhabditis elegans

[AKT-1(KD)]

mgEx464

Caenorhabditis elegans

[pdk-1(KD)]

mgEx465

Caenorhabditis elegans

[pdk-1(KD)]

wlzIs6

Caenorhabditis elegans

[human LRRK2(KD)]

wlzIs7

Caenorhabditis elegans

[human LRRK2(R1441C/KD)]

vwIs213

Caenorhabditis elegans

[pie-1::GFP::AIR-2-KD]

SWF5

Caenorhabditis elegans

npp-10

Caenorhabditis elegans

Enables RNA binding activity. Involved in several processes, including mitotic chromosome centromere condensation; nuclear pore localization; and protein localization to organelle. Located in P granule; kinetochore; and nuclear envelope. Part of nuclear pore. Human ortholog(s) of this gene implicated in T-cell acute lymphoblastic leukemia. Is an ortholog of human NUP98 (nucleoporin 98 and 96 precursor).

npp-14

Caenorhabditis elegans

Enables caspase binding activity. Involved in negative regulation of execution phase of apoptosis. Predicted to be located in nuclear membrane. Predicted to be part of nuclear pore. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; acute myeloid leukemia; and brain disease. Is an ortholog of human NUP214 (nucleoporin 214).

prp-8

Caenorhabditis elegans

Predicted to enable pre-mRNA intronic binding activity and snRNA binding activity. Predicted to be involved in spliceosomal tri-snRNP complex assembly. Predicted to be located in nucleus. Predicted to be part of U5 snRNP and catalytic step 2 spliceosome. Expressed in germ line. Used to study retinitis pigmentosa 13. Human ortholog(s) of this gene implicated in retinitis pigmentosa 13. Is an ortholog of human PRPF8 (pre-mRNA processing factor 8).