- gene: aipl-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable actin filament binding activity. Involved in actin filament organization and regulation of protein localization. Predicted to be located in cortical actin cytoskeleton. Expressed in body wall musculature; head neurons; intestine; and spermatheca. Is an ortholog of human WDR1 (WD repeat domain 1).
- gene: klp-20 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables microtubule motor activity. Involved in microtubule-based movement. Part of axonemal heterotrimeric kinesin-II complex. Expressed in ciliated neurons; distal tip cell; head; touch receptor neurons; and ventral nerve cord. Human ortholog(s) of this gene implicated in silicosis. Is an ortholog of human KIF3A (kinesin family member 3A).
- gene: lsy-27 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in neuron differentiation and regulation of DNA-templated transcription. Predicted to be located in nucleus. Expressed in ASE; embryonic cell; head; somatic nervous system; and tail neurons.
- gene: klp-11 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables microtubule motor activity. Involved in microtubule-based movement. Part of axonemal heterotrimeric kinesin-II complex. Expressed in amphid neurons; dorsal nerve cord; inner labial neurons; phasmid neurons; and ventral nerve cord. Human ortholog(s) of this gene implicated in retinitis pigmentosa 89. Is an ortholog of human KIF3B (kinesin family member 3B) and KIF3C (kinesin family member 3C).
- gene: sup-12 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables pre-mRNA intronic binding activity and single-stranded RNA binding activity. Involved in several processes, including alternative mRNA splicing, via spliceosome; regulation of actin cytoskeleton organization; and regulation of alternative mRNA splicing, via spliceosome. Located in nuclear speck. Part of ribonucleoprotein complex. Is an ortholog of human RBM24 (RNA binding motif protein 24) and RBM38 (RNA binding motif protein 38).
- gene: unc-78 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables actin filament binding activity. Involved in several processes, including myofibril assembly; regulation of actin polymerization or depolymerization; and regulation of locomotion. Located in myofibril and sarcoplasm. Expressed in body wall musculature; pharynx; spermatheca; uterus; and vulva. Is an ortholog of human WDR1 (WD repeat domain 1).
- gene: asd-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables pre-mRNA intronic binding activity and single-stranded RNA binding activity. Involved in regulation of alternative mRNA splicing, via spliceosome. Located in P granule and nucleus. Part of ribonucleoprotein complex. Expressed in body wall musculature; hypodermis; and pharyngeal muscle cell. Is an ortholog of human QKI (QKI, KH domain containing RNA binding).
- gene: wwp-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables ubiquitin conjugating enzyme activity. Involved in defense response to bacterium; protein ubiquitination; and regulation of protein catabolic process. Acts upstream of or within determination of adult lifespan. Located in cytoplasm. Expressed in GABAergic neurons; cholinergic neurons; coelomocyte; somatic neurons; and vulval muscle. Is an ortholog of human WWP1 (WW domain containing E3 ubiquitin protein ligase 1) and WWP2 (WW domain containing E3 ubiquitin protein ligase 2).
- strain: NK2621
Caenorhabditis elegans - strain: pCW10
Caenorhabditis elegans