JK3091

Caenorhabditis elegans

sdhd-1

Caenorhabditis elegans

Contributes to succinate dehydrogenase (quinone) activity. Predicted to be involved in mitochondrial electron transport, succinate to ubiquinone and tricarboxylic acid cycle. Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex II (succinate dehydrogenase). Human ortholog(s) of this gene implicated in Carney-Stratakis syndrome; mitochondrial complex II deficiency; and paraganglioma. Is an ortholog of human SDHD (succinate dehydrogenase complex subunit D).

kin-2

Caenorhabditis elegans

Predicted to enable cAMP binding activity; cAMP-dependent protein kinase inhibitor activity; and protein kinase A catalytic subunit binding activity. Involved in several processes, including medium-term memory; negative regulation of oocyte maturation; and negative regulation of protein kinase C signaling. Located in cytosol and membrane. Part of cAMP-dependent protein kinase complex. Expressed in body wall musculature; hypodermis; and intestine. Human ortholog(s) of this gene implicated in Carney complex; acrodysostosis; and primary pigmented nodular adrenocortical disease. Is an ortholog of human PRKAR1B (protein kinase cAMP-dependent type I regulatory subunit beta).

mev-1

Caenorhabditis elegans

Contributes to succinate dehydrogenase (quinone) activity. Involved in several processes, including defense response to other organism; determination of adult lifespan; and regulation of response to oxidative stress. Located in mitochondrion. Human ortholog(s) of this gene implicated in several diseases, including Carney-Stratakis syndrome; gastrointestinal stromal tumor; and paraganglioma. Is an ortholog of human SDHC (succinate dehydrogenase complex subunit C).

sdhb-1

Caenorhabditis elegans

Contributes to succinate dehydrogenase (quinone) activity. Predicted to be involved in aerobic respiration and respiratory electron transport chain. Located in mitochondrion. Expressed in head and tail. Used to study paraganglioma. Human ortholog(s) of this gene implicated in several diseases, including Carney-Stratakis syndrome; gastrointestinal stromal tumor; and mitochondrial complex II deficiency. Is an ortholog of human SDHB (succinate dehydrogenase complex iron sulfur subunit B).