F47B8.10

Caenorhabditis elegans

Predicted to enable glucose 6-phosphate:phosphate antiporter activity. Predicted to be involved in glucose-6-phosphate transport and phosphate ion transmembrane transport. Predicted to be located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type II; glycogen storage disease Ib; and glycogen storage disease Ic. Is an ortholog of human SLC37A4 (solute carrier family 37 member 4).

C07E3.9

Caenorhabditis elegans

Predicted to enable calcium ion binding activity and phospholipase A2 activity. Predicted to be involved in arachidonic acid secretion; lipid catabolic process; and phospholipid metabolic process. Predicted to be located in extracellular region. Is an ortholog of human PLA2G1B (phospholipase A2 group IB).

C05C8.7

Caenorhabditis elegans

Predicted to enable mannose-6-phosphate isomerase activity. Predicted to be involved in GDP-mannose biosynthetic process. Predicted to be located in cytosol. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ib. Is an ortholog of human MPI (mannose phosphate isomerase).

syx-16

Caenorhabditis elegans

Predicted to enable SNAP receptor activity and SNARE binding activity. Predicted to be involved in intracellular protein transport; vesicle docking; and vesicle fusion. Predicted to be located in endomembrane system. Predicted to be part of SNARE complex. Human ortholog(s) of this gene implicated in pseudohypoparathyroidism type IB. Is an ortholog of human STX16 (syntaxin 16).

C42C1.19

Caenorhabditis elegans

Predicted to enable glucose 6-phosphate:phosphate antiporter activity. Predicted to be involved in glucose-6-phosphate transport and phosphate ion transmembrane transport. Predicted to be located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type II; glycogen storage disease Ib; and glycogen storage disease Ic. Is an ortholog of human SLC37A4 (solute carrier family 37 member 4).

ZK632.4

Caenorhabditis elegans

Predicted to enable mannose-6-phosphate isomerase activity. Predicted to be involved in GDP-mannose biosynthetic process. Predicted to be located in cytosol. Expressed in amphid neurons; head neurons; hypodermis; intestine; and nervous system. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ib. Is an ortholog of human MPI (mannose phosphate isomerase).

tag-51

Caenorhabditis elegans

Enriched in body wall musculature; germ line; and neurons based on RNA-seq and microarray studies. Is affected by several genes including etr-1; csr-1; and hsf-1 based on RNA-seq and microarray studies. Is affected by five chemicals including stavudine; paraquat; and Colistin based on RNA-seq and microarray studies. Is predicted to encode a protein with the following domain: SL1/TIF-IB Complex Component. Is an ortholog of human TAF1A (TATA-box binding protein associated factor, RNA polymerase I subunit A).

seb-3

Caenorhabditis elegans

Predicted to enable G protein-coupled peptide receptor activity. Involved in behavioral response to ethanol; locomotory behavior; and response to heat. Located in axon and neuronal cell body. Expressed in body wall musculature; nervous system; ray 1; and rectal gland cell. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in several diseases, including achalasia; inflammatory bowel disease (multiple); and isolated growth hormone deficiency type IB. Is an ortholog of several human genes including ADCYAP1R1 (ADCYAP receptor type I); GHRHR (growth hormone releasing hormone receptor); and GIPR (gastric inhibitory polypeptide receptor).

hum-6

Caenorhabditis elegans

Predicted to enable actin filament binding activity and microfilament motor activity. Predicted to be involved in several processes, including actin filament-based process; endocytosis; and sensory perception of sound. Predicted to be located in several cellular components, including actin cytoskeleton; cytoplasm; and microvillus. Predicted to be part of myosin VI complex. Human ortholog(s) of this gene implicated in several diseases, including Usher syndrome type 1; auditory system disease (multiple); and congenital nystagmus. Is an ortholog of human MYO7A (myosin VIIA).

dhrr-1

Caenorhabditis elegans

Predicted to enable G protein-coupled peptide receptor activity. Predicted to be involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. Expressed in M.vlpaaapp; M.vlpaapaa; M.vrpaaapp; M.vrpaapaa; and head muscle. Human ortholog(s) of this gene implicated in achalasia; inflammatory bowel disease (multiple); and isolated growth hormone deficiency type IB. Is an ortholog of several human genes including ADCYAP1R1 (ADCYAP receptor type I); GHRHR (growth hormone releasing hormone receptor); and GLP1R (glucagon like peptide 1 receptor).