NWG0383

Caenorhabditis elegans

C56E6.7

Caenorhabditis elegans

Enriched in ADE sheath cell; IL socket cell; and neurons based on RNA-seq and single-cell RNA-seq studies. Is affected by several genes including mrps-5; lpd-3; and clk-1 based on microarray and RNA-seq studies.

algn-9

Caenorhabditis elegans

Predicted to enable alpha-1,2-mannosyltransferase activity. Predicted to be involved in protein N-linked glycosylation. Predicted to be located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Il. Is an ortholog of human ALG9 (ALG9 alpha-1,2-mannosyltransferase).

F16B12.5

Caenorhabditis elegans

Enriched in ABalpapaap; ABarappaap; IL socket cell; and M3L based on single-cell RNA-seq studies. Is affected by several genes including mut-2; drh-3; and rrf-2 based on tiling array; RNA-seq; and microarray studies. Is affected by four chemicals including rifampin; Psoralens; and Sirolimus based on RNA-seq and microarray studies.

argk-1

Caenorhabditis elegans

Predicted to enable kinase activity. Involved in ATP metabolic process and generation of precursor metabolites and energy. Predicted to be located in extracellular space. Expressed in IL socket cell and OL socket cell. Is an ortholog of several human genes including CKB (creatine kinase B); CKM (creatine kinase, M-type); and CKMT1B (creatine kinase, mitochondrial 1B).

ZK688.1

Caenorhabditis elegans

Enriched in IL socket cell; arc ant V; dopaminergic neurons; and mechanosensory neurons based on tiling array and single-cell RNA-seq studies. Is affected by several genes including etr-1; ash-2; and rrf-3 based on microarray and RNA-seq studies. Is affected by six chemicals including rifampin; allantoin; and Chlorpyrifos based on RNA-seq and microarray studies.

pugs-7

Caenorhabditis elegans

Enriched in IL socket cell; arc ant V; hyp3; and neurons based on tiling array; single-cell RNA-seq; and RNA-seq studies. Is affected by several genes including drh-3; rrf-3; and mrps-5 based on microarray and RNA-seq studies. Is affected by methylmercuric chloride; Colistin; and Sirolimus based on microarray studies. Is predicted to encode a protein with the following domain: C6 domain.

fbxb-82

Caenorhabditis elegans

Enriched in IL socket cell; NSM; and tail precursor cell based on tiling array and single-cell RNA-seq studies. Is affected by several genes including cyc-1; atx-3; and drh-3 based on microarray and RNA-seq studies. Is affected by fifteen chemicals including methylmercuric chloride; Alovudine; and stavudine based on microarray and RNA-seq studies. Is predicted to encode a protein with the following domains: F-box associated; F-box domain; Zygotic Embryogenesis-Associated Protein; and F-box associated domain, type 2.

djr-1.2

Caenorhabditis elegans

Predicted to enable glyoxalase III activity. Involved in cellular aldehyde metabolic process; cellular response to aldehyde; and monocarboxylic acid biosynthetic process. Located in cytoplasm. Expressed in several structures, including excretory canal; inner labial neurons; phasmid neurons; rectal gland cell; and ventral nerve cord. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in Parkinson's disease 7; Parkinsonism; and middle cerebral artery infarction. Is an ortholog of human PARK7 (Parkinsonism associated deglycase).

top-1

Caenorhabditis elegans

Enables DNA topoisomerase type I (single strand cut, ATP-independent) activity. Predicted to be involved in DNA replication; DNA topological change; and chromosome segregation. Located in nucleolus and spindle pole centrosome. Expressed in several structures, including IL socket cell; excretory cell; gonad; intestine; and neurons. Is an ortholog of human TOP1 (DNA topoisomerase I) and TOP1MT (DNA topoisomerase I mitochondrial).