SJZ42

Caenorhabditis elegans

anc-1

Caenorhabditis elegans

Predicted to enable actin binding activity and kinesin binding activity. Involved in cytoskeleton organization; nucleus organization; and pronuclear migration. Located in nuclear envelope and perinuclear region of cytoplasm. Expressed in several structures, including body wall musculature; intestinal cell; and vulval muscle. Used to study Emery-Dreifuss muscular dystrophy. Human ortholog(s) of this gene implicated in arthrogryposis multiplex congenita-3; autosomal dominant Emery-Dreifuss muscular dystrophy 4; autosomal dominant Emery-Dreifuss muscular dystrophy 5; autosomal recessive spinocerebellar ataxia 8; and bipolar disorder. Is an ortholog of human SYNE1 (spectrin repeat containing nuclear envelope protein 1).

lmn-1

Caenorhabditis elegans

Enables histone binding activity; identical protein binding activity; and structural molecule activity. Involved in several processes, including determination of adult lifespan; nuclear pore localization; and regulation of cell cycle. Located in nuclear envelope and nuclear periphery. Expressed in several structures, including ventral cord blast cell. Used to study Emery-Dreifuss muscular dystrophy; congenital muscular dystrophy; and progeria. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease type 2B1; autosomal dominant Emery-Dreifuss muscular dystrophy 2; autosomal recessive Emery-Dreifuss muscular dystrophy 3; brain disease (multiple); congenital muscular dystrophy due to LMNA mutation; and intrinsic cardiomyopathy (multiple). Is an ortholog of human LMNA (lamin A/C).

unc-83

Caenorhabditis elegans

Enables dynein light chain binding activity. Involved in several processes, including egg-laying behavior; protein localization to nuclear envelope; and vulval development. Located in nuclear outer membrane. Expressed in several structures, including P1; P12; P2; P3; and P9. Used to study Emery-Dreifuss muscular dystrophy.

lem-2

Caenorhabditis elegans

Enables chromatin DNA binding activity and lamin binding activity. Involved in several processes, including microtubule organizing center organization; nuclear membrane reassembly; and response to X-ray. Located in chromosome and nuclear envelope. Used to study Emery-Dreifuss muscular dystrophy and cataract 46 juvenile-onset. Human ortholog(s) of this gene implicated in Buschke-Ollendorff syndrome and cataract 46 juvenile-onset. Is an ortholog of human LEMD2 (LEM domain nuclear envelope protein 2) and LEMD3 (LEM domain containing 3).

emr-1

Caenorhabditis elegans

Enables lamin binding activity. Involved in several processes, including mitotic cytokinesis; nuclear envelope organization; and response to X-ray. Located in nuclear inner membrane. Used to study Emery-Dreifuss muscular dystrophy. Is an ortholog of human LEMD1 (LEM domain containing 1).

zyg-12

Caenorhabditis elegans

Enables dynein light intermediate chain binding activity. Involved in several processes, including centrosome localization; chromosome segregation; and pronuclear migration. Located in centrosome and nuclear envelope. Expressed in gonad and oocyte. Used to study Emery-Dreifuss muscular dystrophy. Is an ortholog of human HOOK1 (hook microtubule tethering protein 1) and HOOK2 (hook microtubule tethering protein 2).