H12D21.10

Caenorhabditis elegans

Predicted to enable protein O-acetylglucosaminyltransferase activity. Predicted to be involved in protein O-GlcNAcylation via threonine. Predicted to be located in endoplasmic reticulum lumen. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome. Is an ortholog of human EOGT (EGF domain specific O-linked N-acetylglucosamine transferase).

rrc-1

Caenorhabditis elegans

Enables GTPase activator activity. Predicted to be involved in signal transduction. Expressed in GLRL; GLRR; coelomocyte; excretory cell; and uterine seam cell. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome and coronary artery disease. Is an ortholog of human ARHGAP33 (Rho GTPase activating protein 33).

F46H5.4

Caenorhabditis elegans

Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in small GTPase-mediated signal transduction. Human ortholog(s) of this gene implicated in several diseases, including Adams-Oliver syndrome; developmental and epileptic encephalopathy 23; and gastrointestinal system cancer (multiple). Is an ortholog of human DOCK8 (dedicator of cytokinesis 8).

dsl-4

Caenorhabditis elegans

Predicted to enable Notch binding activity. Predicted to be involved in cell communication. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in several diseases, including Adams-Oliver syndrome; limb ischemia; and temporal arteritis. Is an ortholog of human DLL1 (delta like canonical Notch ligand 1) and DLL4 (delta like canonical Notch ligand 4).

spe-9

Caenorhabditis elegans

Predicted to enable signaling receptor binding activity. Involved in single fertilization. Located in several cellular components, including cell surface; cytoplasm; and pseudopodium. Expressed in sperm and spermatid. Human ortholog(s) of this gene implicated in several diseases, including Adams-Oliver syndrome; limb ischemia; and temporal arteritis. Is an ortholog of human DLL1 (delta like canonical Notch ligand 1) and DLL4 (delta like canonical Notch ligand 4).

lag-1

Caenorhabditis elegans

Enables Notch binding activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and transcription coactivator binding activity. Involved in several processes, including cell differentiation; dauer exit; and regulation of DNA-templated transcription. Located in nucleus. Part of RNA polymerase II transcription regulator complex and chromatin. Expressed in several structures, including P4.p; P5.p; P6.p; P7.p; and P8.p. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome and dilated cardiomyopathy. Is an ortholog of human RBPJ (recombination signal binding protein for immunoglobulin kappa J region).