Questions, Feedback & Help
Send us an email and we'll get back to you ASAP. Or you can read our Frequently Asked Questions.
  • page settings
  • hide sidebar
  • show empty fields
  • layout
  • (too narrow)
  • open all
  • close all
Resources » Paper

Guan, Guoye et al. (2021) International Worm Meeting "Speed and fate diversity tradeoff in nematode's early embryogenesis"

  • History

  • Referenced

  • Tree Display

  • My Favorites

  • My Library

  • Comments on Guan, Guoye et al. (2021) International Worm Meeting "Speed and fate diversity tradeoff in nematode's early embryogenesis" (0)

  • Overview

    Status:
    Publication type:
    Meeting_abstract
    WormBase ID:
    WBPaper00063190

    Guan, Guoye, Wong, Ming-Kin, Zhao, Zhongying, Tang, Lei-Han, & Tang, Chao (2021). Speed and fate diversity tradeoff in nematode's early embryogenesis presented in International Worm Meeting. Unpublished information; cite only with author permission.

    Nematode species are well-known for their invariant cell lineage pattern during development. Combining knowledge about the fate specification induced by asymmetric division and the anti-correlation between cell cycle length and cell volume in Caenorhabditis elegans, we propose a model to simulate lineage initiation by altering cell volume segregation ratio in each division, and quantify the derived pattern's performance in proliferation speed, fate diversity and space robustness. The stereotypic pattern in C. elegans embryo is found to be one of the most optimal solutions taking minimum time to achieve the cell number before gastrulation, by programming asymmetric divisions as a strategy (Guan, et al. arXiv, 2021, 2007.05723).

    Affiliations:
    - Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China
    - Beijing Computational Science Research Center, Beijing, China
    - Department of Physics and Institute of Computational and Theoretical Studies, Hong Kong Baptist University, Hong Kong, China
    - Department of Biology, Hong Kong Baptist University, Hong Kong, China
    - School of Physics, Peking University, Beijing, China
    - State Key Laboratory of Environmental and Biological Analysis, Hong Kong Baptist University, Hong Kong, China
    - Center for Quantitative Biology, Peking University, Beijing, China


    Tip: Seeing your name marked red? Please help us identify you.