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Resources » Paper

Katlin B Massirer et al. (2004) West Coast Worm Meeting "The role of PAZ/PIWI domain proteins in the sex-determination/dosage compensation pathway."

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    Status:
    Publication type:
    Meeting_abstract
    WormBase ID:
    WBPaper00023994

    Katlin B Massirer, & Amy Pasquinelli (2004). The role of PAZ/PIWI domain proteins in the sex-determination/dosage compensation pathway presented in West Coast Worm Meeting. Unpublished information; cite only with author permission.

    In C. elegans sex is determined by the number of X chromosomes and dosage compensation is achieved by regulation of X-signal elements. In hermaphrodites, the nuclear receptor sex-1 transcriptionally represses xol-1 , which is important for the activation of dosage compensation and the hermaphrodite mode of sex determination (Carmi & Meyer, 1999). We found that a member of the PAZ/PIWI domain (PPD) family of proteins genetically interacts with the sex-1 gene. PPD proteins have been implicated in various biological pathways including embryonic patterning and stem cell maintenance. PPD proteins function in the RNAi and microRNA pathways and may elicit their biological effects by controlling the expression and function of the ~ 22 nucleotide RNAs that direct these processes. We are currently exploring the role of specific PPD proteins and miRNA in the C. elegans sex-determination/dosage compensation pathway.


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